Al-Khateeb S N, Tarazi S J, Al Maaitah E F, Al-Batayneh O B, Abu Alhaija E S J
Department of Preventive Dentistry, Faculty of Dentistry, School of Dentistry, Jordan University of Science and Technology, P.O. Box 3030, Irbid, Jordan,
Eur Arch Paediatr Dent. 2014 Dec;15(6):413-9. doi: 10.1007/s40368-014-0131-2. Epub 2014 Jun 21.
To investigate the effect of acid etching procedure on the remineralisation of white spot lesions (WSL) which had undergone an initial phase of arrest, and to compare between the effect of fluoride and/or CPP-ACP on remineralisation before and after acid etching.
In vitro study.
WSL were prepared in vitro on 130 human enamel slabs which were allocated into four experimental groups (N = 30) and one control group (N = 10). Changes in mineral content were registered weekly by Quantitative Light Induced Fluorescence QLF. When changes had arrested (after 8 weeks), the enamel surface of 20 slabs in each group were acid etched. The remineralisation process was continued until it slowed down again (after 5 weeks).
Mean fluorescence gain was 13.7 ± 0.9% in the fluoride group, 16.5 ± 1.1% in the CPP-ACP group, and 11.4 ± 1.2% in the combination of fluoride and CPP-ACP group.
There was a tendency toward better remineralisation after acid etching but this did not reach a significant level; the effect of etching was more pronounced in the presence of fluoride. Although CPP-ACP seemed to give a steadier rate of remineralisation over time when compared with fluoride, the overall remineralisation in the regimens was similar. In this model, combined treatment of fluoride and CPP-ACP did not have an extra benefit over the fluoride or CPP-ACP alone.
研究酸蚀程序对已进入初始静止期的白斑病变（WSL）再矿化的影响，并比较酸蚀前后氟化物和/或酪蛋白磷酸肽-无定形磷酸钙（CPP-ACP）对再矿化的影响。
体外研究。
在130个人类牙釉质片上体外制备WSL，将其分为四个实验组（n = 30）和一个对照组（n = 10）。每周通过定量光诱导荧光（QLF）记录矿物质含量的变化。当变化停止（8周后），对每组20个牙釉质片的表面进行酸蚀。再矿化过程持续进行直至再次减缓（5周后）。
氟化物组的平均荧光增加为13.7±0.9%，CPP-ACP组为16.5±1.1%，氟化物与CPP-ACP联合组为11.4±1.2%。
酸蚀后有再矿化更好的趋势，但未达到显著水平；在有氟化物存在时，蚀刻的效果更明显。尽管与氟化物相比，CPP-ACP似乎随着时间推移能使再矿化速率更稳定，但各方案中的总体再矿化情况相似。在该模型中，氟化物与CPP-ACP联合治疗并不比单独使用氟化物或CPP-ACP有额外益处。
