Berdai Mohamed Adnane, Labib Smael, Harandou Mustapha
Child and Mother Intensive Care Unit, University Hospital Hassan II, Sidi Hrazem Avenue, 30000 Fes, Morocco.
Case Rep Emerg Med. 2014;2014:783236. doi: 10.1155/2014/783236. Epub 2014 May 14.
Peganum harmala L. is a plant widely distributed in the Mediterranean region. It is commonly used in traditional medicine in Morocco as sedative and abortifacient but exposes users to the risk of overdose and poisoning. The pharmacologically active compounds of this plant include a number of β -carboline and quinazoline alkaloids responsible of its pharmacological and toxicological effects. We report the case of a 24-year-old woman, 22 weeks pregnant, intoxicated with the seeds of Peganum harmala L. On admission, she had disturbance of consciousness, uterine contraction, and oliguria. Laboratory tests revealed renal failure and liver injury, and she benefited then from hemodialysis. During hospitalization, she was intubated after deterioration of consciousness and presented a spontaneous expulsion of the fetus. After extubation, she kept unusual sequelae: cerebellar ataxia and peripheral polyneuropathy. Physicians in regions using Peganum harmala L. as traditional medicine must be able to detect symptoms of its toxicity, in order to establish early gastrointestinal decontamination. The prognosis of this intoxication is variable; most cases can be managed successfully; but in high doses of intoxication, evolution can be fatal.
骆驼蓬是一种广泛分布于地中海地区的植物。在摩洛哥，它常用于传统医学中作为镇静剂和堕胎药，但会使使用者面临过量和中毒风险。这种植物的药理活性成分包括多种β-咔啉和喹唑啉生物碱，这些生物碱是其药理和毒理作用的原因。我们报告了一例24岁、怀孕22周的女性因摄入骆驼蓬种子而中毒的病例。入院时，她有意识障碍、子宫收缩和少尿。实验室检查显示肾衰竭和肝损伤，随后她接受了血液透析治疗。住院期间，她在意识恶化后插管，并出现胎儿自然排出。拔管后，她留下了异常后遗症：小脑共济失调和周围性多发性神经病。在将骆驼蓬用作传统药物的地区，医生必须能够检测出其毒性症状，以便尽早进行胃肠道去污处理。这种中毒的预后各不相同；大多数病例可以成功治疗；但在高剂量中毒时，病情发展可能是致命的。
