Jurel Sunit Kumar, Gupta Durga Shanker, Singh Raghuwar D, Singh Mrinalini, Srivastava Shilpi
Department of Prosthodontics, Faculty of Dental Sciences, King George, Lucknow, Uttar Pradesh, India.
Departments of Oral and Maxillofacial Surgery, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India.
Indian J Hum Genet. 2014 Jan;20(1):4-9. doi: 10.4103/0971-6866.132745.
Oral cancers have been one of the leading causes of deaths particularly in the developing countries. Prime reason for this high mortality and morbidity is attributed to the delay in diagnosis and prompt treatment. Relentless research in the field of oncology has led to the advent of novel procedures for the early detection of oral cancers. Molecular biology is highly promising in this regard. It is a procedure that detects alterations at a molecular level much before they are seen under a microscope and much before clinical changes occur. Molecular studies serve as the basis by which we will eventually be able not only to augment clinical assessment and classification of oral lesions but also predict malignant potential of oral lesions, thus reducing the incidence and increasing the scope for early diagnosis and treatment of oral cancers. However, making such sophisticated tools available for the common man in developing countries is one of the most important challenges faced today.
口腔癌一直是主要的死亡原因之一,尤其是在发展中国家。造成这种高死亡率和高发病率的主要原因是诊断延误和治疗不及时。肿瘤学领域的不懈研究导致了早期检测口腔癌的新方法的出现。分子生物学在这方面极具前景。这是一种在分子水平上检测变化的方法,远在显微镜下可见之前以及临床变化出现之前就能检测到。分子研究是我们最终不仅能够加强口腔病变的临床评估和分类,而且能够预测口腔病变恶性潜能的基础,从而降低口腔癌的发病率,增加早期诊断和治疗的机会。然而,让发展中国家的普通人能够使用这些精密工具是当今面临的最重要挑战之一。