Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
Basic Health Science, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
Evid Based Complement Alternat Med. 2014;2014:724658. doi: 10.1155/2014/724658. Epub 2014 May 18.
The cancer is probably the most dreaded disease in both men and women and also major health problem worldwide. Despite its high prevalence, the exact molecular mechanisms of the development and progression are not fully understood. The current chemotherapy/radiotherapy regime used to treat cancer shows adverse side effect and may alter gene functions. Natural products are generally safe, effective, and less expensive substitutes of anticancer chemotherapeutics. Based on previous studies of their potential therapeutic uses, Nigella sativa and its constituents may be proved as good therapeutic options in the prevention of cancer. Black seeds are used as staple food in the Middle Eastern Countries for thousands of years and also in the treatment of diseases. Earlier studies have shown that N. sativa and its constituent thymoquinone (TQ) have important roles in the prevention and treatment of cancer by modulating cell signaling pathways. In this review, we summarize the role of N. sativa and its constituents TQ in the prevention of cancer through the activation or inactivation of molecular cell signaling pathways.
癌症可能是男性和女性最可怕的疾病，也是全球主要的健康问题。尽管它的发病率很高，但癌症发生和发展的确切分子机制尚未完全了解。目前用于治疗癌症的化疗/放疗方案显示出不良反应，并且可能改变基因功能。天然产物通常是安全、有效且价格较低的抗癌化学疗法替代品。基于其潜在治疗用途的先前研究，Nigella sativa 及其成分可能被证明是预防癌症的良好治疗选择。黑种子在中东国家已被用作主食数千年来，也用于治疗疾病。早期研究表明，N. sativa 和其成分百里醌（TQ）通过调节细胞信号通路在癌症的预防和治疗中发挥重要作用。在这篇综述中，我们总结了 N. sativa 及其成分 TQ 通过激活或失活分子细胞信号通路在预防癌症中的作用。
