Dior Uri P, Kogan Liron, Chill Henry H, Eizenberg Neta, Simon Alexander, Revel Ariel
Department of Obstetrics and Gynecology, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Department of Obstetrics and Gynecology, Rabin Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel.
Semin Reprod Med. 2014 Sep;32(5):402-9. doi: 10.1055/s-0034-1376359. Epub 2014 Jun 24.
Embryo implantation requires a reciprocal interaction between the blastocyst and endometrium and is associated with complex regulatory mechanisms. Since their discovery, microRNAs have become prominent regulatory candidates, providing missing links for many biological pathways. In recent years, microRNAs have been implicated as one of the important players in the regulation of multiple physiological functions of the endometrium. This review aims to present recent knowledge pertaining to the diverse aspects of microRNAs in the embryo-endometrial cross talk. We will focus on the role of microRNAs in decidualization. Next, we will review recent studies investigating the role of microRNAs in recurrent pregnancy loss. Finally, we will discuss the role of microRNAs in the tissue invasion of implantation and compare that with tissue invasion in cancers.
胚胎着床需要囊胚与子宫内膜之间的相互作用，并与复杂的调节机制相关。自发现以来，微小RNA已成为重要的调节候选分子，为许多生物学途径提供了缺失的环节。近年来，微小RNA被认为是子宫内膜多种生理功能调节中的重要参与者之一。本综述旨在介绍有关微小RNA在胚胎-子宫内膜相互作用不同方面的最新知识。我们将重点关注微小RNA在蜕膜化中的作用。接下来，我们将综述近期研究微小RNA在复发性流产中作用的研究。最后，我们将讨论微小RNA在着床组织侵袭中的作用，并将其与癌症中的组织侵袭进行比较。
