Minodier Laëtitia, Arena Christophe, Heuze Guillaume, Ruello Marc, Amoros Jean Pierre, Souty Cécile, Varesi Laurent, Falchi Alessandra
EA7310, Laboratoire de Virologie, Université de Corse, Institut national de la Santé et de la Recherche Médicale, Corte, France.
EA7310, Laboratoire de Virologie, Université de Corse, Institut national de la Santé et de la Recherche Médicale, Corte, France; Observatoire régional de la Santé de Corse, Ajaccio, France.
PLoS One. 2014 Jun 24;9(6):e100388. doi: 10.1371/journal.pone.0100388. eCollection 2014.
Influenza-like illness (ILI) surveillance is important to identify circulating and emerging/reemerging strains and unusual epidemiological trends. The present study aimed to give an accurate picture of the 2012-2013 ILI outbreak in Corsica by combining data from several surveillance systems: general practice, emergency general practice, hospital emergency units, intensive care units, and nursing homes. Twenty-eight respiratory viruses were retrospectively investigated from patients in general practice with ILI. Sequence analysis of the genetic changes in the hemagglutinin gene of influenza viruses (A(H1N1)pdm2009, A(H3N2) and B) was performed. The trends in ILI/influenza consultation rates and the relative illness ratios (RIRs) of having an ILI consultation were estimated by age group for the different surveillance systems analyzed. Of the 182 ILI patients enrolled by general practitioners, 57.7% tested positive for influenza viruses. Phylogenetic analyses suggested a genetic drift for influenza B and A(H3N2) viruses. The ILI/influenza surveillance systems showed similar trends and were well correlated. In accordance with virological data, the RIRs of having an ILI consultation were highest among the young (<15 years old) and decreased with age. No clusters of acute respiratory illness were declared by the sentinel nursing homes. This study is noteworthy in that it is the first extensive description of the 2012-2013 ILI outbreak in Corsica as monitored through several surveillance systems. To improve ILI surveillance in Corsica, a consortium that links together the complementary regional surveillance ILI systems described here is being implemented.
流感样疾病（ILI）监测对于识别正在传播的以及新出现/再次出现的毒株和异常的流行病学趋势至关重要。本研究旨在通过整合来自多个监测系统的数据，准确呈现2012 - 2013年科西嘉岛ILI疫情的情况，这些监测系统包括：普通诊所、急诊普通诊所、医院急诊科、重症监护病房和疗养院。对普通诊所中患有ILI的患者进行了28种呼吸道病毒的回顾性调查。对流感病毒（A(H1N1)pdm2009、A(H3N2)和B）血凝素基因的基因变化进行了序列分析。针对所分析的不同监测系统，按年龄组估算了ILI/流感咨询率以及进行ILI咨询的相对患病比率（RIR）。在普通科医生登记的182例ILI患者中，57.7%的流感病毒检测呈阳性。系统发育分析表明乙型流感病毒和A(H3N2)病毒存在基因漂移。ILI/流感监测系统呈现出相似的趋势且相关性良好。根据病毒学数据，进行ILI咨询的RIR在年轻人（<15岁）中最高，并随年龄增长而降低。定点疗养院未报告急性呼吸道疾病聚集性病例。本研究值得注意，因为它是通过多个监测系统对2012 - 2013年科西嘉岛ILI疫情的首次广泛描述。为改善科西嘉岛的ILI监测，一个将此处描述的互补性区域ILI监测系统联系在一起的联盟正在实施。
