Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai 400 019, India.
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai 400 019, India.
J Control Release. 2014 Sep 10;189:25-45. doi: 10.1016/j.jconrel.2014.06.021. Epub 2014 Jun 21.
The medical device industry is growing at a very fast pace and has recorded great research activity over the past decade. The interdisciplinary nature of this field has made it possible for researchers to incorporate principles from various allied areas like pharmaceutics, bioengineering, biotechnology, chemistry, electronics, biophysics etc. to develop superior medical solutions, offering better prospects to the patient. Moreover, micro and nanotechnology have made it possible to positively affect at the sub-micron scales, the cellular processes initiated upon implantation. Literature is rife with findings on various implants and this review comprehensively summarizes the recent advances in micro/nanoscale implantable medical devices - particularly cardiovascular implants, neural implants, orthopedic and dental implants and other miscellaneous implants. Over the years, medical implants have metamorphosed from mere support providing devices to smart interventions participating positively in the healing process. We have highlighted the current research in each area emphasizing on the value addition provided by micro/nanoscale features, its course through the past and the future perspectives focusing on the unmet needs.
医疗器械行业发展迅速,在过去十年中记录了大量的研究活动。该领域的跨学科性质使得研究人员能够将药剂学、生物工程、生物技术、化学、电子、生物物理学等各个相关领域的原理结合起来,开发出更优越的医疗解决方案,为患者带来更好的前景。此外,微纳技术使得有可能在亚微米尺度上积极影响植入后引发的细胞过程。文献中充斥着各种植入物的发现,本综述全面总结了微/纳米级可植入医疗器械的最新进展——特别是心血管植入物、神经植入物、骨科和牙科植入物以及其他各种植入物。多年来,医疗植入物已经从仅仅提供支撑的设备演变为积极参与愈合过程的智能干预措施。我们强调了每个领域的当前研究,重点介绍了微/纳米级特征提供的附加值,其发展历程,以及关注未满足需求的未来展望。