Garaci Enrico, Russo Matteo Antonio, Pariano Marilena, Puccetti Matteo, Fabi Consuelo, Balucchi Sarah, Bellet Marina Maria, Ricci Maurizio, Fini Massimo, Romani Luigina
San Raffaele Research Center, 67039 Sulmona, Italy.
IRCCS San Raffaele, 00163 Rome, Italy.
Int J Mol Sci. 2025 Sep 6;26(17):8687. doi: 10.3390/ijms26178687.
This article explores an integrative framework for medical rehabilitation that combines regenerative medicine, systemic homeostasis, and microbiome modulation to optimize recovery and long-term health. Moving beyond conventional rehabilitation approaches focused on symptomatic recovery, this multidimensional paradigm emphasizes cellular repair, physiological balance, and microbial health as interdependent pillars of effective recovery. The framework leverages advancements in stem cell therapy, immune system modulation, and microbiota-targeted interventions to address both immediate functional restoration and long-term systemic resilience. By highlighting the synergistic interplay between these components, this article provides actionable insights into transforming medical rehabilitation into a proactive and holistic endeavor, paving the way for enhanced therapeutic outcomes and sustained patient well-being.
本文探讨了一种医学康复的综合框架，该框架结合了再生医学、系统稳态和微生物群调节，以优化康复效果和长期健康。超越专注于症状缓解的传统康复方法，这种多维度范式强调细胞修复、生理平衡和微生物健康是有效康复的相互依存的支柱。该框架利用干细胞治疗、免疫系统调节和针对微生物群的干预措施的进展，来解决即时功能恢复和长期系统恢复力的问题。通过强调这些组成部分之间的协同相互作用，本文提供了可操作的见解，以将医学康复转变为一种积极主动的整体努力，为提高治疗效果和患者的持续福祉铺平道路。
