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儿童和青少年非特应性哮喘/喘息的危险因素：一项系统综述

Risk factors for non-atopic asthma/wheeze in children and adolescents: a systematic review.

作者信息

Strina Agostino, Barreto Mauricio L, Cooper Philip J, Rodrigues Laura C

机构信息

Universidade Federal da Bahia, Instituto de Saude Coletiva, Rua Basilio da Gama s/n, 40110-040 Salvador, Bahia, Brazil.

St George's University of London, Division of Clinical Sciences, Cranmer Terrace, London SW17 ORE, UK.

出版信息

Emerg Themes Epidemiol. 2014 Jun 6;11:5. doi: 10.1186/1742-7622-11-5. eCollection 2014.

DOI:10.1186/1742-7622-11-5
PMID:24963333
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4068161/
Abstract

BACKGROUND

The study of non-atopic asthma/wheeze in children separately from atopic asthma is relatively recent. Studies have focused on single risk factors and had inconsistent findings.

OBJECTIVE

To review evidence on factors associated with non-atopic asthma/wheeze in children and adolescents.

METHODS

A review of studies of risk factors for non-atopic asthma/wheeze which had a non-asthmatic comparison group, and assessed atopy by skin-prick test or allergen-specific IgE.

RESULTS

Studies of non-atopic asthma/wheeze used a wide diversity of definitions of asthma/wheeze, comparison groups and methods to assess atopy. Among 30 risk factors evaluated in the 43 studies only 3 (family history of asthma/rhinitis/eczema, dampness/mold in the household, and lower respiratory tract infections in childhood) showed consistent associations with non-atopic asthma/wheeze. No or limited period of breastfeeding was less consistently associated with non-atopic asthma/wheeze. The few studies examining the effects of overweight/obesity and psychological/social factors showed consistent associations. We used a novel graphical presentation of different risk factors for non-atopic asthma/wheeze, allowing a more complete perception of the complex pattern of effects.

CONCLUSIONS

More research using standardized methodology is needed on the causes of non-atopic asthma.

摘要

背景

将儿童非特应性哮喘/喘息与特应性哮喘分开研究是相对较新的。以往研究聚焦于单一风险因素，结果并不一致。

目的

综述与儿童及青少年非特应性哮喘/喘息相关因素的证据。

方法

对有非哮喘对照组且通过皮肤点刺试验或过敏原特异性IgE评估特应性的非特应性哮喘/喘息风险因素研究进行综述。

结果

非特应性哮喘/喘息的研究对哮喘/喘息、对照组及评估特应性的方法采用了多种不同定义。在43项研究中评估的30个风险因素里，只有3个（哮喘/鼻炎/湿疹家族史、家庭潮湿/霉菌、儿童期下呼吸道感染）与非特应性哮喘/喘息呈现出一致的关联。无母乳喂养或母乳喂养时间有限与非特应性哮喘/喘息的关联不太一致。少数研究超重/肥胖和心理/社会因素的影响呈现出一致的关联。我们使用了一种新颖的图形展示非特应性哮喘/喘息的不同风险因素，以便更全面地了解复杂的效应模式。

结论

需要更多采用标准化方法的研究来探究非特应性哮喘的病因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd2/4068161/f30f37593b7f/1742-7622-11-5-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd2/4068161/bbb82119ea15/1742-7622-11-5-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd2/4068161/f30f37593b7f/1742-7622-11-5-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd2/4068161/bbb82119ea15/1742-7622-11-5-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd2/4068161/f30f37593b7f/1742-7622-11-5-2.jpg

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本文引用的文献

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2
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Clin Exp Allergy. 2013 Jul;43(7):762-74. doi: 10.1111/cea.12107.
3
Asthma phenotypes and endotypes: an evolving paradigm for classification.
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PLoS One. 2024 Sep 30;19(9):e0310647. doi: 10.1371/journal.pone.0310647. eCollection 2024.
4
Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme.拉丁美洲哮喘的认识与控制：基于SCAALA项目的近期研究综述
Clin Transl Allergy. 2023 Mar;13(3):e12232. doi: 10.1002/clt2.12232.
5
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6
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