Pajno Giovanni B, Cox Linda, Caminiti Lucia, Ramistella Vincenzo, Crisafulli Giuseppe
Allergy Unit, Department of Pediatrics, University of Messina , Messina, Italy .
Nova Southeastern University , Fort Lauderdale, Florida.
Pediatr Allergy Immunol Pulmonol. 2014 Jun 1;27(2):42-50. doi: 10.1089/ped.2014.0332.
Today, there is neither an effective nor an active treatment for food allergy. Allergy immunotherapy has been proposed as an attractive strategy to actively treat food allergy. Oral immunotherapy (OIT), also known as oral desensitization, is a method of inducing the body's immune system to tolerate a food that causes an allergic overreaction. It has been studied for the use in treatment of immunoglobulin E-mediated food allergy to the most common foods, including milk, egg, and peanut. OIT has been able to desensitize subjects to varying degrees. However, many questions remain unanswered, including efficient formulation, optimal dosing, and induction protocol to achieve full tolerance, transition of OIT to clinical practice, and maximal safety profile. This review focuses on the use of OIT as a new and active treatment for food allergy. The possibility of transition of OIT to clinical practice represents, in this field, the next pivotal step with the goal of improving the quality of life of patients with food allergy and their families.
如今，对于食物过敏既没有有效的治疗方法，也没有积极的治疗手段。过敏免疫疗法已被提议作为一种积极治疗食物过敏的有吸引力的策略。口服免疫疗法（OIT），也称为口服脱敏疗法，是一种诱导人体免疫系统耐受引起过敏过度反应食物的方法。它已被研究用于治疗对包括牛奶、鸡蛋和花生在内的最常见食物的免疫球蛋白E介导的食物过敏。口服免疫疗法已能够使受试者在不同程度上脱敏。然而，许多问题仍未得到解答，包括有效的配方、最佳剂量以及实现完全耐受的诱导方案、口服免疫疗法向临床实践的转变以及最大安全概况。本综述重点关注口服免疫疗法作为一种治疗食物过敏的新型积极疗法的应用。在该领域，口服免疫疗法向临床实践转变的可能性代表着朝着改善食物过敏患者及其家庭生活质量这一目标迈出的下一个关键步骤。
