Kramer Victor G, Byrareddy Siddappa N
McGill AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada.
Expert Rev Vaccines. 2014 Aug;13(8):935-7. doi: 10.1586/14760584.2014.928597. Epub 2014 Jun 26.
The success of vaccine regimens against viral pathogens hinges on the elicitation of protective responses. Hypervariable pathogens such as HIV avoid neutralization by masking protective epitopes with more immunogenic decoys. The identification of protective, conserved epitopes is crucial for future vaccine candidate design. The strategies employed for identification of HIV protective epitopes will also aid towards rational vaccine design for other viral pathogens.
针对病毒病原体的疫苗方案的成功取决于诱导保护性反应。像HIV这样的高变异性病原体通过用更多具有免疫原性的诱饵掩盖保护性表位来避免被中和。鉴定保护性保守表位对于未来候选疫苗的设计至关重要。用于鉴定HIV保护性表位的策略也将有助于其他病毒病原体的合理疫苗设计。
