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夜香树花不同提取物的体外抗氧化、抗增殖及植物化学研究

In vitro antioxidant, antiproliferative, and phytochemical study in different extracts of Nyctanthes arbortristis flowers.

作者信息

Khanapur Manjulatha, Avadhanula Ravi K, Setty Oruganti H

机构信息

Department of Biochemistry, School of Life Sciences, University of Hyderabad, Professor C. R. Rao Road, Gachibowli, Hyderabad, Andhra Pradesh 500 046, India.

出版信息

Biomed Res Int. 2014;2014:291271. doi: 10.1155/2014/291271. Epub 2014 May 20.

DOI:10.1155/2014/291271
PMID:24967346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4055216/
Abstract

Nyctanthes arbortristis L. (Oleaceae) is widely used in the Indian system of traditional medicine and is reported to have various biological activities. The present study was intended to evaluate the antioxidant and antiproliferative activities of flower extracts of Nyctanthes arbortristis. The shade dried flowers were extracted with 95% ethanol under sonication and the antioxidant activities were investigated using in vitro assays along with the determination of phytochemical constituents (total polyphenol and total flavonoid). Arborside C and β-monogentiobioside ester of α-Crocetin were identified in crude active extracts through LCMS/MS analysis. The antiproliferative activity was carried out by MTT assay by employing different human cancer cell lines. The lowest IC50 value of 24.56 ± 6.63 μg/mL was observed against Colo 205 cell line. The extract exhibited significant antioxidant and antiproliferative properties and the observed biological activities in this study provide scientific validation of ethnomedicinal use of this plant.

摘要

夜花树（Nyctanthes arbortristis L.，木犀科）在印度传统医学体系中被广泛应用，据报道具有多种生物活性。本研究旨在评估夜花树花提取物的抗氧化和抗增殖活性。将阴干的花在超声处理下用95%乙醇提取，通过体外试验以及植物化学成分（总多酚和总黄酮）的测定来研究抗氧化活性。通过液相色谱 - 质谱/质谱分析在粗活性提取物中鉴定出了梓醇C和α - 藏红花素的β - 龙胆二糖苷酯。采用不同的人类癌细胞系通过MTT法进行抗增殖活性检测。观察到对Colo 205细胞系的最低半数抑制浓度（IC50）值为24.56 ± 6.63 μg/mL。该提取物表现出显著的抗氧化和抗增殖特性，本研究中观察到的生物活性为该植物的民族药用提供了科学验证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/272a/4055216/a1b155ba6651/BMRI2014-291271.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/272a/4055216/5c783f9899e2/BMRI2014-291271.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/272a/4055216/478d26301ca5/BMRI2014-291271.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/272a/4055216/51d2bf44cb6f/BMRI2014-291271.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/272a/4055216/a67b9046bc90/BMRI2014-291271.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/272a/4055216/7c731bfb3a43/BMRI2014-291271.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/272a/4055216/a1b155ba6651/BMRI2014-291271.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/272a/4055216/5c783f9899e2/BMRI2014-291271.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/272a/4055216/478d26301ca5/BMRI2014-291271.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/272a/4055216/51d2bf44cb6f/BMRI2014-291271.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/272a/4055216/a67b9046bc90/BMRI2014-291271.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/272a/4055216/7c731bfb3a43/BMRI2014-291271.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/272a/4055216/a1b155ba6651/BMRI2014-291271.006.jpg

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