氧化应激对儿童白血病治疗期间症状发生、严重程度及痛苦的影响。
The influence of oxidative stress on symptom occurrence, severity, and distress during childhood leukemia treatment.
作者信息
Hockenberry Marilyn J, Taylor Olga A, Pasvogel Alice, Rodgers Cheryl, McCarthy Kathy, Gundy Patricia, Montgomery David W, Ribbeck Phillip, Scheurer Michael E, Moore Ida M Ki
机构信息
School of Nursing, Duke University, Durham, NC.
College of Medicine, Baylor University, Houston, TX.
出版信息
Oncol Nurs Forum. 2014 Jul 1;41(4):E238-47. doi: 10.1188/14.ONF.E238-E247.
PURPOSE/OBJECTIVES: To explore the symptom trajectory during the first 16 months of childhood leukemia treatment and any associations with the oxidative stress pathway measured by cerebrospinal fluid (CSF) concentration of oxidized phosphatidylcholine (PC), the predominant glycerophospholipid in the brain and cell membranes.
DESIGN
Prospective, longitudinal design.
SETTING
Two cancer centers in the southwestern United States.
SAMPLE
36 children (aged 3-14 years) newly diagnosed with acute lymphoblastic leukemia.
METHODS
Symptoms were measured using the Memorial Symptom Assessment Scale at six specific time points during treatment. Biochemical changes in oxidative stress were measured by oxidized PC in the CSF.
MAIN RESEARCH VARIABLES
Childhood cancer symptoms, oxidized PC.
FINDINGS
Significant differences were found in the number of symptoms experienced during the three phases of treatment. Symptom trajectory changes and influence of the oxidative stress pathway on symptom experiences were identified.
CONCLUSIONS
Symptoms experienced during treatment for childhood leukemia are associated with increased oxidative stress.
IMPLICATIONS FOR NURSING
Children with leukemia experience symptoms throughout treatment. Physiologic measures indicate the influence of oxidative stress on symptoms.
目的/目标：探讨儿童白血病治疗头16个月期间的症状轨迹，以及与通过脑脊液（CSF）中氧化磷脂酰胆碱（PC）浓度测量的氧化应激途径的任何关联，氧化磷脂酰胆碱是大脑和细胞膜中主要的甘油磷脂。
设计
前瞻性纵向设计。
地点
美国西南部的两个癌症中心。
样本
36名新诊断为急性淋巴细胞白血病的儿童（3 - 14岁）。
方法
在治疗期间的六个特定时间点使用纪念症状评估量表测量症状。通过脑脊液中的氧化PC测量氧化应激的生化变化。
主要研究变量
儿童癌症症状、氧化PC。
结果
在治疗的三个阶段中经历的症状数量存在显著差异。确定了症状轨迹变化以及氧化应激途径对症状体验的影响。
结论
儿童白血病治疗期间经历的症状与氧化应激增加有关。
对护理的启示
白血病患儿在整个治疗过程中都会出现症状。生理指标表明氧化应激对症状的影响。
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