Rodgers Cheryl C, Hooke Mary C, Taylor Olga A, Koerner Kari M, Mitby Pauline A, Moore Ida M, Scheurer Michael E, Hockenberry Marilyn J, Pan Wei
Duke University.
University of Minnesota.
Oncol Nurs Forum. 2019 Mar 1;46(2):228-237. doi: 10.1188/19.ONF.228-237.
To examine the relationship of the Childhood Cancer Symptom Cluster-Leukemia (CCSC-L) with health-related quality of life (HRQOL).
SAMPLE & SETTING: 327 children receiving treatment for acute lymphoblastic leukemia from four pediatric oncology programs across the United States.
METHODS & VARIABLES: Participants completed fatigue, sleep disturbance, pain, nausea, and depression symptom questionnaires at four time points; these symptoms comprised the CCSC-L. HRQOL was measured at the start of postinduction therapy and then at the start of maintenance therapy. Relationships between the CCSC-L and HRQOL scores were examined with longitudinal parallel-process modeling.
The mean HRQOL significantly increased over time (p < 0.001). The CCSC-L had a significant negative association with HRQOL scores at the start of postinduction therapy (beta = -0.53, p < 0.005) and the start of maintenance therapy (beta = -0.33, p < 0.015). Participants with more severe symptoms in the CCSC-L over time had significantly lower HRQOL at the start of maintenance therapy (beta = -0.42, p < 0.005).
Nurses are pivotal in providing management strategies to minimize symptom severity that may improve HRQOL.
探讨儿童癌症症状群 - 白血病（CCSC - L）与健康相关生活质量（HRQOL）之间的关系。
来自美国四个儿科肿瘤项目的327名接受急性淋巴细胞白血病治疗的儿童。
参与者在四个时间点完成疲劳、睡眠障碍、疼痛、恶心和抑郁症状问卷；这些症状构成了CCSC - L。在诱导治疗后开始时以及维持治疗开始时测量HRQOL。使用纵向平行过程模型研究CCSC - L与HRQOL得分之间的关系。
HRQOL的平均值随时间显著增加（p < 0.001）。CCSC - L在诱导治疗后开始时（β = -0.53，p < 0.005）和维持治疗开始时（β = -0.33，p < 0.015）与HRQOL得分存在显著负相关。随着时间推移，CCSC - L中症状更严重的参与者在维持治疗开始时的HRQOL显著更低（β = -0.42，p < 0.005）。
护士在提供管理策略以最小化可能改善HRQOL的症状严重程度方面起着关键作用。
