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属于USA300和EMRSA - 15克隆谱系的两种高产生物膜形成金黄色葡萄球菌分离株的全基因组序列

Complete Genome Sequences of Two Prolific Biofilm-Forming Staphylococcus aureus Isolates Belonging to USA300 and EMRSA-15 Clonal Lineages.

作者信息

Sabirova J S, Xavier B B, Hernalsteens J-P, De Greve H, Ieven M, Goossens H, Malhotra-Kumar S

机构信息

Department of Medical Microbiology, Vaccine & Infectious Disease Institute, Universiteit Antwerpen, Antwerp, Belgium.

Viral Genetics Research Group, Vrije Universiteit Brussel, Brussels, Belgium.

出版信息

Genome Announc. 2014 Jun 26;2(3):e00610-14. doi: 10.1128/genomeA.00610-14.

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) causes serious infections that are even more difficult to treat when associated with a biofilm phenotype that facilitates evasion of the host immune system and antibiotics. As a first step toward understanding the mechanisms underlying biofilm formation, we sequenced the genomes of two prolific biofilm-forming strains belonging to the two most important globally disseminated clonal lineages, USA300 and EMRSA-15.

摘要

耐甲氧西林金黄色葡萄球菌(MRSA)会引发严重感染,当它与生物膜表型相关联时,治疗起来会更加困难,因为这种表型有助于逃避宿主免疫系统和抗生素的作用。作为了解生物膜形成潜在机制的第一步,我们对属于全球传播最广的两个最重要克隆谱系USA300和EMRSA - 15的两株高产生物膜形成菌株的基因组进行了测序。

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