Sabirova J S, Xavier B B, Hernalsteens J-P, De Greve H, Ieven M, Goossens H, Malhotra-Kumar S
Department of Medical Microbiology, Vaccine & Infectious Disease Institute, Universiteit Antwerpen, Antwerp, Belgium.
Viral Genetics Research Group, Vrije Universiteit Brussel, Brussels, Belgium.
Genome Announc. 2014 Jun 26;2(3):e00610-14. doi: 10.1128/genomeA.00610-14.
Methicillin-resistant Staphylococcus aureus (MRSA) causes serious infections that are even more difficult to treat when associated with a biofilm phenotype that facilitates evasion of the host immune system and antibiotics. As a first step toward understanding the mechanisms underlying biofilm formation, we sequenced the genomes of two prolific biofilm-forming strains belonging to the two most important globally disseminated clonal lineages, USA300 and EMRSA-15.
耐甲氧西林金黄色葡萄球菌(MRSA)会引发严重感染,当它与生物膜表型相关联时,治疗起来会更加困难,因为这种表型有助于逃避宿主免疫系统和抗生素的作用。作为了解生物膜形成潜在机制的第一步,我们对属于全球传播最广的两个最重要克隆谱系USA300和EMRSA - 15的两株高产生物膜形成菌株的基因组进行了测序。