National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India.
Department of Bioengineering, University of California, Riverside, CA 92521, USA.
Mol Immunol. 2014 Oct;61(2):89-99. doi: 10.1016/j.molimm.2014.06.004. Epub 2014 Jun 27.
The complement system surveillance in the host is effective in controlling viral propagation. Consequently, to subvert this effector mechanism, viruses have developed a series of adaptations. One among these is encoding mimics of host regulators of complement activation (RCA) which help viruses to avoid being labeled as 'foreign' and protect them from complement-mediated neutralization and complement-enhanced antiviral adaptive immunity. In this review, we provide an overview on the structure, function and evolution of viral RCA proteins.
宿主中的补体系统监测可有效控制病毒的传播。因此，为了颠覆这种效应机制，病毒已经发展出一系列的适应机制。其中之一是编码宿主补体激活调节剂（RCA）的模拟物，这有助于病毒避免被标记为“外来”，并保护它们免受补体介导的中和作用和补体增强的抗病毒适应性免疫。在这篇综述中，我们提供了病毒 RCA 蛋白的结构、功能和进化的概述。
