Thurston Rebecca C, Ewing Linda J, Low Carissa A, Christie Aimee J, Levine Michele D
From the 1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA; Departments of 3Psychology and 4Medicine, University of Pittsburgh, Pittsburgh, PA; and 5Mental Health Care Line, Michael E. DeBakey VA Medical Center, Houston, TX.
Menopause. 2015 Jan;22(1):59-65. doi: 10.1097/GME.0000000000000274.
Although adiposity has been considered to be protective against hot flashes, newer data suggest positive relationships between hot flashes and adiposity. No studies have been specifically designed to test whether weight loss reduces hot flashes. This pilot study aimed to evaluate the feasibility, acceptability, and initial efficacy of behavioral weight loss in reducing hot flashes.
Forty overweight or obese women with hot flashes (≥ 4 hot flashes/d) were randomized to either behavioral weight loss intervention or wait-list control. Hot flashes were assessed before and after intervention via physiologic monitoring, diary, and questionnaire. Comparisons of changes in hot flashes and anthropometrics between conditions were performed via Wilcoxon tests.
Study retention (83%) and intervention satisfaction (93.8%) were high. Most women (74.1%) reported that hot flash reduction was a major motivator for losing weight. Women randomized to the weight loss intervention lost more weight (-8.86 kg) than did women randomized to control (+0.23 kg; P < 0.0001). Women randomized to weight loss also showed greater reductions in questionnaire-reported hot flashes (2-wk hot flashes, -63.0) than did women in the control group (-28.0; P = 0.03)-a difference not demonstrated in other hot flash measures. Reductions in weight and hot flashes were significantly correlated (eg, r = 0.47, P = 0.006).
This pilot study shows a behavioral weight loss program that is feasible, acceptable, and effective in producing weight loss among overweight or obese women with hot flashes. Findings indicate the importance of a larger study designed to test behavioral weight loss for hot flash reduction. Hot flash management could motivate women to engage in this health-promoting behavior.
尽管肥胖一直被认为对潮热有保护作用，但最新数据表明潮热与肥胖之间存在正相关关系。尚无专门设计用于测试体重减轻是否能减少潮热的研究。这项初步研究旨在评估行为减肥在减少潮热方面的可行性、可接受性和初步疗效。
40名有潮热症状（≥4次/天）的超重或肥胖女性被随机分为行为减肥干预组或等待名单对照组。通过生理监测、日记和问卷在干预前后评估潮热情况。通过Wilcoxon检验对不同组间潮热和人体测量学变化进行比较。
研究保留率（83%）和干预满意度（93.8%）很高。大多数女性（74.1%）报告称潮热减轻是减肥的主要动力。随机分配到减肥干预组的女性体重减轻幅度（-8.86千克）大于随机分配到对照组的女性（+0.23千克；P<0.0001）。随机分配到减肥组的女性在问卷报告的潮热方面也比对照组女性有更大幅度的减少（2周潮热次数，-63.0），而在其他潮热测量指标中未显示出这种差异。体重减轻和潮热减少显著相关（例如，r = 0.47，P = 0.006）。
这项初步研究表明，行为减肥计划对于有潮热症状的超重或肥胖女性来说是可行、可接受且有效的减肥方法。研究结果表明开展一项更大规模研究以测试行为减肥对减少潮热的作用具有重要意义。潮热管理可能会促使女性参与这种促进健康的行为。
