Okamoto T, Ohno Y, Tsugane S, Watanabe S, Shimoyama M, Tajima K, Miwa M, Shimotohno K
Virology Division, National Cancer Center, Tokyo.
Jpn J Cancer Res. 1989 Mar;80(3):191-5. doi: 10.1111/j.1349-7006.1989.tb02289.x.
The age-specific occurrence of adult T-cell leukemia (ATL) was analyzed using 357 cases collected during nationwide surveys carried out between 1982 and 1985 in Japan. A simple Weibull distribution function fitted well as a model. The mode of ATL onset was log-linear in this model and the curves for males and females overlapped completely. The presence of age-dependent accumulation of leukemogenic events within human T-cell leukemia virus type 1-immortalized T cells was suggested prior to the development of ATL, and the approximate number of independent leukemogenic events in ATL is estimated to be five. This stochastic analysis supported a multi-step carcinogenesis as an appropriate model for ATL.
利用1982年至1985年在日本全国范围内进行的调查收集的357例病例，分析了成人T细胞白血病（ATL）的年龄特异性发病率。一个简单的威布尔分布函数作为模型拟合得很好。在该模型中，ATL发病模式呈对数线性，男性和女性的曲线完全重叠。这表明在ATL发生之前，人T细胞白血病病毒1型永生化T细胞内存在与年龄相关的致白血病事件积累，并且估计ATL中独立致白血病事件的大致数量为五个。这种随机分析支持多步骤致癌作用作为ATL的合适模型。
