乳酸乳球菌基因中参与苹果酸-乳酸发酵所需的产物与一个正调控因子家族同源。
Product of the Lactococcus lactis gene required for malolactic fermentation is homologous to a family of positive regulators.
作者信息
Renault P, Gaillardin C, Heslot H
机构信息
Laboratoire de Génétique des Microorganismes, INA P-G/CBAI, Thiverval-Grignon, France.
出版信息
J Bacteriol. 1989 Jun;171(6):3108-14. doi: 10.1128/jb.171.6.3108-3114.1989.
Abstract
Malolactic fermentation is a secondary fermentation that many lactic acid bacteria can carry out when L-malate is present in the medium. The activation of the malolactic system in Lactococcus lactis is mediated by a locus we call mleR. Induction of the genes necessary to perform malolactic fermentation occurs only in bacteria with a functional copy of mleR. The mleR gene consists of one open reading frame capable of coding for a protein with a calculated molecular mass of 33,813 daltons. The amino acid sequence of the predicted MleR gene product is homologous to that of positive activators in gram-negative bacteria: LysR, IlvY gene products of Escherichia coli, MetR, CysB of Salmonella typhimurium, AmpR of Enterobacter cloacae, NodD of Rhizobium sp., and TrpI of Pseudomonas aeruginosa.
摘要
苹果酸-乳酸发酵是一种二次发酵，当培养基中存在L-苹果酸时，许多乳酸菌都能进行这种发酵。乳酸乳球菌中苹果酸-乳酸系统的激活由一个我们称为mleR的基因座介导。进行苹果酸-乳酸发酵所需基因的诱导仅发生在具有功能性mleR拷贝的细菌中。mleR基因由一个开放阅读框组成，该开放阅读框能够编码一种计算分子量为33813道尔顿的蛋白质。预测的MleR基因产物的氨基酸序列与革兰氏阴性菌中的阳性激活剂同源：大肠杆菌的LysR、IlvY基因产物，鼠伤寒沙门氏菌的MetR、CysB，阴沟肠杆菌的AmpR，根瘤菌的NodD，以及铜绿假单胞菌的TrpI。
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