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1
Product of the Lactococcus lactis gene required for malolactic fermentation is homologous to a family of positive regulators.乳酸乳球菌基因中参与苹果酸-乳酸发酵所需的产物与一个正调控因子家族同源。
J Bacteriol. 1989 Jun;171(6):3108-14. doi: 10.1128/jb.171.6.3108-3114.1989.
2
Cloning, sequence and expression of the gene encoding the malolactic enzyme from Lactococcus lactis.乳酸乳球菌苹果酸乳酸酶编码基因的克隆、测序及表达
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3
Absence of malolactic activity is a characteristic of H+-ATPase-deficient mutants of the lactic acid bacterium Oenococcus oeni.缺乏苹果酸-乳酸代谢活性是乳酸细菌酒类酒球菌H⁺-ATP酶缺陷型突变体的一个特征。
Appl Environ Microbiol. 2003 Apr;69(4):1973-9. doi: 10.1128/AEM.69.4.1973-1979.2003.
4
Genetic organization of the mle locus and identification of a mleR-like gene from Leuconostoc oenos.酒酒球菌中mle基因座的遗传组织及类mleR基因的鉴定。
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5
Functional expression in Saccharomyces cerevisiae of the Lactococcus lactis mleS gene encoding the malolactic enzyme.编码苹果酸乳酸酶的乳酸乳球菌mleS基因在酿酒酵母中的功能表达。
FEMS Microbiol Lett. 1995 Jan 1;125(1):37-43. doi: 10.1111/j.1574-6968.1995.tb07332.x.
6
Sequence of the Pseudomonas aeruginosa trpI activator gene and relatedness of trpI to other procaryotic regulatory genes.铜绿假单胞菌trpI激活基因的序列以及trpI与其他原核调控基因的相关性。
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7
Cloning and sequence analysis of the gene encoding Lactococcus lactis malolactic enzyme: relationships with malic enzymes.乳酸乳球菌苹果酸乳酸酶编码基因的克隆与序列分析：与苹果酸酶的关系
FEMS Microbiol Lett. 1994 Feb 1;116(1):79-86. doi: 10.1111/j.1574-6968.1994.tb06679.x.
8
Malolactic fermentation: electrogenic malate uptake and malate/lactate antiport generate metabolic energy.苹果酸-乳酸发酵：电生性苹果酸摄取及苹果酸/乳酸反向转运产生代谢能量。
J Bacteriol. 1991 Oct;173(19):6030-7. doi: 10.1128/jb.173.19.6030-6037.1991.
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Characterization of mleR, a positive regulator of malolactic fermentation and part of the acid tolerance response in Streptococcus mutans.鉴定 mleR，其为变链菌中苹果酸-乳酸发酵的正调控因子和耐酸应答的一部分。
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Malolactic fermentation by engineered Saccharomyces cerevisiae as compared with engineered Schizosaccharomyces pombe.与工程改造的粟酒裂殖酵母相比，工程改造的酿酒酵母进行的苹果酸乳酸发酵。
Yeast. 1996 Mar 15;12(3):215-25. doi: 10.1002/(SICI)1097-0061(19960315)12:3%3C215::AID-YEA903%3E3.0.CO;2-M.

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An underlying mechanism for MleR activating the malolactic enzyme pathway to enhance acid tolerance in L9.MleR 通过激活苹果酸-乳酸酶途径增强 L9 耐酸性的潜在机制。
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6
Autoinducer-2-regulated genes in Streptococcus mutans UA159 and global metabolic effect of the luxS mutation.变形链球菌UA159中自诱导物-2调控的基因及luxS突变的全局代谢效应
J Bacteriol. 2008 Jan;190(1):401-15. doi: 10.1128/JB.01086-07. Epub 2007 Nov 2.
7
The 2-hydroxycarboxylate transporter family: physiology, structure, and mechanism.2-羟基羧酸盐转运蛋白家族：生理学、结构与机制
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8
Insertion-sequence-mediated mutations isolated during adaptation to growth and starvation in Lactococcus lactis.在乳酸乳球菌适应生长和饥饿过程中分离出的插入序列介导的突变。
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9
Absence of malolactic activity is a characteristic of H+-ATPase-deficient mutants of the lactic acid bacterium Oenococcus oeni.缺乏苹果酸-乳酸代谢活性是乳酸细菌酒类酒球菌H⁺-ATP酶缺陷型突变体的一个特征。
Appl Environ Microbiol. 2003 Apr;69(4):1973-9. doi: 10.1128/AEM.69.4.1973-1979.2003.
10
Genetic manipulation of Lactococcus lactis by using targeted group II introns: generation of stable insertions without selection.利用靶向II组内含子对乳酸乳球菌进行基因操作：无需筛选即可产生稳定插入
Appl Environ Microbiol. 2003 Feb;69(2):1121-8. doi: 10.1128/AEM.69.2.1121-1128.2003.

本文引用的文献

1
The Rhizobium leguminosarum nodulation gene nodF encodes a polypeptide similar to acyl-carrier protein and is regulated by nodD plus a factor in pea root exudate.根瘤菌属植物的结瘤基因 nodF 编码一种与酰基辅酶 A 相似的多肽，受 nodD 以及豌豆根分泌物中的一个因子调控。
EMBO J. 1986 Apr;5(4):647-52. doi: 10.1002/j.1460-2075.1986.tb04262.x.
2
Improved medium for lactic streptococci and their bacteriophages.用于乳酸链球菌及其噬菌体的改良培养基。
Appl Microbiol. 1975 Jun;29(6):807-13. doi: 10.1128/am.29.6.807-813.1975.
3
Selection of Streptococcus lactis Mutants Defective in Malolactic Fermentation.筛选乳酸发酵缺陷型乳链球菌突变株。
Appl Environ Microbiol. 1987 Feb;53(2):320-4. doi: 10.1128/aem.53.2.320-324.1987.
4
Malolactic enzyme of Lactobacillus plantarum. Purification, properties, and distribution among bacteria.植物乳杆菌的苹果酸乳酸酶。纯化、性质及在细菌中的分布
J Biol Chem. 1983 Apr 25;258(8):4907-10.
5
Cascades of Sigma factors.西格玛因子级联反应。
Cell. 1981 Sep;25(3):582-4. doi: 10.1016/0092-8674(81)90164-1.
6
Evidence for a coding pattern on the non-coding strand of the E. coli genome.大肠杆菌基因组非编码链上编码模式的证据。
Nucleic Acids Res. 1984 Mar 12;12(5):2235-41. doi: 10.1093/nar/12.5.2235.
7
Regulation of diaminopimelate decarboxylase synthesis in Escherichia coli. III. Nucleotide sequence and regulation of the lysR gene.大肠杆菌中二氨基庚二酸脱羧酶合成的调控。III. lysR基因的核苷酸序列及调控
J Mol Biol. 1983 Aug 5;168(2):333-50. doi: 10.1016/s0022-2836(83)80022-9.
8
New versatile plasmid vectors for expression of hybrid proteins coded by a cloned gene fused to lacZ gene sequences encoding an enzymatically active carboxy-terminal portion of beta-galactosidase.新型多功能质粒载体，用于表达由与编码β-半乳糖苷酶酶活性羧基末端部分的lacZ基因序列融合的克隆基因所编码的杂交蛋白。
Gene. 1983 Nov;25(1):71-82. doi: 10.1016/0378-1119(83)90169-5.
9
Protein-DNA recognition.蛋白质-脱氧核糖核酸识别
Annu Rev Biochem. 1984;53:293-321. doi: 10.1146/annurev.bi.53.070184.001453.
10
Nucleotide sequences that signal the initiation of transcription and translation in Bacillus subtilis.在枯草芽孢杆菌中指示转录和翻译起始的核苷酸序列。
Mol Gen Genet. 1982;186(3):339-46. doi: 10.1007/BF00729452.

乳酸乳球菌基因中参与苹果酸-乳酸发酵所需的产物与一个正调控因子家族同源。

Product of the Lactococcus lactis gene required for malolactic fermentation is homologous to a family of positive regulators.

作者信息

Renault P, Gaillardin C, Heslot H

机构信息

Laboratoire de Génétique des Microorganismes, INA P-G/CBAI, Thiverval-Grignon, France.

出版信息

J Bacteriol. 1989 Jun;171(6):3108-14. doi: 10.1128/jb.171.6.3108-3114.1989.

DOI:10.1128/jb.171.6.3108-3114.1989
PMID:2498286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC210022/
Abstract

Malolactic fermentation is a secondary fermentation that many lactic acid bacteria can carry out when L-malate is present in the medium. The activation of the malolactic system in Lactococcus lactis is mediated by a locus we call mleR. Induction of the genes necessary to perform malolactic fermentation occurs only in bacteria with a functional copy of mleR. The mleR gene consists of one open reading frame capable of coding for a protein with a calculated molecular mass of 33,813 daltons. The amino acid sequence of the predicted MleR gene product is homologous to that of positive activators in gram-negative bacteria: LysR, IlvY gene products of Escherichia coli, MetR, CysB of Salmonella typhimurium, AmpR of Enterobacter cloacae, NodD of Rhizobium sp., and TrpI of Pseudomonas aeruginosa.

摘要

苹果酸-乳酸发酵是一种二次发酵，当培养基中存在L-苹果酸时，许多乳酸菌都能进行这种发酵。乳酸乳球菌中苹果酸-乳酸系统的激活由一个我们称为mleR的基因座介导。进行苹果酸-乳酸发酵所需基因的诱导仅发生在具有功能性mleR拷贝的细菌中。mleR基因由一个开放阅读框组成，该开放阅读框能够编码一种计算分子量为33813道尔顿的蛋白质。预测的MleR基因产物的氨基酸序列与革兰氏阴性菌中的阳性激活剂同源：大肠杆菌的LysR、IlvY基因产物，鼠伤寒沙门氏菌的MetR、CysB，阴沟肠杆菌的AmpR，根瘤菌的NodD，以及铜绿假单胞菌的TrpI。