Crepaz Nicole, Tungol-Ashmon Malu V, Higa Darrel H, Vosburgh Waverly, Mullins Mary M, Barham Terrika, Adegbite Adebukola, DeLuca Julia B, Sipe Theresa A, White Christina M, Baack Brittney N, Lyles Cynthia M
aPrevention Research Branch, Division of HIV/AIDS Prevention, The U.S. Centers for Disease Control and Prevention bICF International Inc., Atlanta, Georgia, USA.
AIDS. 2014 Mar 13;28(5):633-56. doi: 10.1097/QAD.0000000000000108.
To conduct a systematic review to examine interventions for reducing HIV risk behaviors among people living with HIV (PLWH) in the United States.
Systematic searches included electronic databases from 1988 to 2012, hand searches of journals, reference lists of articles, and HIV/AIDS Internet listservs. Each eligible study was evaluated against the established criteria on study design, implementation, analysis, and strength of findings to assess the risk of bias and intervention effects.
Forty-eight studies were evaluated. Fourteen studies (29%) with both low risk of bias and significant positive intervention effects in reducing HIV transmission risk behaviors were classified as evidence-based interventions (EBIs). Thirty-four studies were classified as non-EBIs due to high risk of bias or nonsignificant positive intervention effects. EBIs varied in delivery from brief prevention messages to intensive multisession interventions. The key components of EBIs included addressing HIV risk reduction behaviors, motivation for behavioral change, misconception about HIV, and issues related to mental health, medication adherence, and HIV transmission risk behavior.
Moving evidence-based prevention for PLWH into practice is an important step in making a greater impact on the HIV epidemic. Efficacious EBIs can serve as model programs for providers in healthcare and nonhealthcare settings looking to implement evidence-based HIV prevention. Clinics and public health agencies at the state, local, and federal levels can use the results of this review as a resource when making decisions that meet the needs of PLWH to achieve the greatest impact on the HIV epidemic.
进行一项系统综述,以研究美国艾滋病毒感染者(PLWH)中降低艾滋病毒风险行为的干预措施。
系统检索包括1988年至2012年的电子数据库、期刊手工检索、文章参考文献列表以及艾滋病毒/艾滋病互联网邮件列表。根据既定的研究设计、实施、分析和研究结果强度标准对每项符合条件的研究进行评估,以评估偏倚风险和干预效果。
共评估了48项研究。14项研究(29%)在降低艾滋病毒传播风险行为方面偏倚风险低且干预效果显著为阳性,被归类为循证干预措施(EBIs)。34项研究因偏倚风险高或干预效果阳性不显著而被归类为非EBIs。EBIs的实施方式各不相同,从简短的预防信息到密集的多阶段干预。EBIs的关键组成部分包括解决降低艾滋病毒风险行为、行为改变的动机、对艾滋病毒的误解以及与心理健康、药物依从性和艾滋病毒传播风险行为相关的问题。
将针对PLWH的循证预防措施付诸实践是对艾滋病毒流行产生更大影响的重要一步。有效的EBIs可为希望实施循证艾滋病毒预防的医疗保健和非医疗保健环境中的提供者提供示范项目。州、地方和联邦各级的诊所和公共卫生机构在做出满足PLWH需求的决策以对艾滋病毒流行产生最大影响时,可将本综述结果作为一种资源。