Cruz Kyria Jayanne Clímaco, de Oliveira Ana Raquel Soares, Pinto Denise Pereira, Morais Jennifer Beatriz Silva, Lima Fabiana da Silva, Colli Célia, Torres-Leal Francisco Leonardo, Marreiro Dilina do Nascimento
Department of Nutrition, Federal University of Piauí, Campus Minister Petrônio Portela, Ininga, Teresina, Piauí, Brazil.
Biol Trace Elem Res. 2014 Sep;160(3):305-10. doi: 10.1007/s12011-014-0044-2. Epub 2014 Jul 2.
The present study evaluated the influence of magnesium on insulin resistance in obese women. A case-control study involving 114 women on the age between 20 and 50 years old, divided into two groups: control (eutrophic women, n = 59) and case (obese women, n = 55). The analysis of magnesium intake was carried out through the 3-day food record and also NutWin software version 1.5. The plasma, erythrocyte, and urinary magnesium concentrations were determined by flame atomic absorption spectrophotometry. The determinations of serum glucose and serum insulin were performed by enzymatic colorimetric method and chemiluminescence, respectively. The insulin resistance was assessed by homeostasis model assessment insulin resistance (HOMA-IR). The mean values of magnesium intake were lower than those recommended, without difference between groups (p > 0.05). All the patients who were evaluated showed adequate mean concentrations of magnesium in the plasma and erythrocyte. The urinary excretion of this mineral was lower than the reference values in both groups and did not show significant difference (p > 0.05). The values of serum glucose, serum insulin, and HOMA-IR were higher in obese women compared to the control group. A negative correlation was observed between erythrocyte magnesium and glycemic parameters (p < 0.05). Obese patients take in foods with low dietary magnesium content, and they show hypomagnesuria as a compensatory mechanism to keep the plasma concentration of this mineral in adequate levels. The correlation between the erythrocyte magnesium concentration and the parameters of glycemic control suggests the influence of this mineral on the index of insulin resistance in obese women.
本研究评估了镁对肥胖女性胰岛素抵抗的影响。一项病例对照研究纳入了114名年龄在20至50岁之间的女性，分为两组：对照组（营养正常女性，n = 59）和病例组（肥胖女性，n = 55）。通过3天食物记录以及NutWin软件1.5版本对镁摄入量进行分析。采用火焰原子吸收分光光度法测定血浆、红细胞和尿镁浓度。分别采用酶比色法和化学发光法测定血清葡萄糖和血清胰岛素。通过稳态模型评估胰岛素抵抗（HOMA-IR）评估胰岛素抵抗。镁摄入量的平均值低于推荐值，两组之间无差异（p > 0.05）。所有接受评估的患者血浆和红细胞中的镁平均浓度均充足。两组中该矿物质的尿排泄量均低于参考值，且无显著差异（p > 0.05）。与对照组相比，肥胖女性的血清葡萄糖、血清胰岛素和HOMA-IR值更高。观察到红细胞镁与血糖参数之间呈负相关（p < 0.05）。肥胖患者摄入的食物中膳食镁含量较低，并且他们表现出低镁尿症作为一种代偿机制，以将这种矿物质的血浆浓度维持在适当水平。红细胞镁浓度与血糖控制参数之间的相关性表明该矿物质对肥胖女性胰岛素抵抗指数有影响。
