1] Center for Personalized NanoMedicine, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199 [2] Electrical and Computer Engineering, College of Engineering, Florida International University, Miami, Florida 33174.
Sci Rep. 2013 Oct 16;3:2953. doi: 10.1038/srep02953.
The nanotechnology capable of high-specificity targeted delivery of anti-neoplastic drugs would be a significant breakthrough in Cancer in general and Ovarian Cancer in particular. We addressed this challenge through a new physical concept that exploited (i) the difference in the membrane electric properties between the tumor and healthy cells and (ii) the capability of magneto-electric nanoparticles (MENs) to serve as nanosized converters of remote magnetic field energy into the MENs' intrinsic electric field energy. This capability allows to remotely control the membrane electric fields and consequently trigger high-specificity drug uptake through creation of localized nano-electroporation sites. In in-vitro studies on human ovarian carcinoma cell (SKOV-3) and healthy cell (HOMEC) lines, we applied a 30-Oe d.c. field to trigger high-specificity uptake of paclitaxel loaded on 30-nm CoFe₂O₄ @BaTiO₃ MENs. The drug penetrated through the membrane and completely eradicated the tumor within 24 hours without affecting the normal cells.
纳米技术能够实现高特异性的抗肿瘤药物靶向递送，这将是癌症治疗领域的重大突破，特别是在卵巢癌治疗方面。我们通过一种新的物理概念来应对这一挑战，该概念利用了（i）肿瘤细胞和健康细胞之间的细胞膜电特性差异，以及（ii）磁电纳米颗粒（MENs）将远程磁场能量转换为MENs 固有电场能量的能力。这种能力允许远程控制细胞膜电场，并通过创建局部纳米电穿孔位点来触发高特异性的药物摄取。在对人卵巢癌细胞（SKOV-3）和健康细胞（HOMEC）系的体外研究中，我们施加了 30 奥斯特的直流磁场来触发载紫杉醇的 30nm CoFe₂O₄@BaTiO₃ MENs 的高特异性摄取。药物穿透细胞膜，在 24 小时内完全根除肿瘤，而不影响正常细胞。
