Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, TX, USA.
J Control Release. 2014 Sep 10;189:108-22. doi: 10.1016/j.jconrel.2014.06.036. Epub 2014 Jun 30.
Controlled delivery of a bioactive to specific organ, cellular and sub-cellular level is a desired feature of a drug carrier system. In order to achieve this goal, formulation scientists search for better alternatives of biomaterials to deliver the therapeutics in more precise and controlled manner in vivo. Zein, a plant protein obtained from corn, is a useful biomaterial for several industrial applications including agriculture, cosmetics, packaging and pharmaceuticals. Being a hydrophobic protein, which is biodegradable, biocompatible, economic to use and with generally regarded safe "GRAS" status, it is an attractive biomaterial for human use. Novel biomedical applications of zein such as controlled and targeted delivery of bioactives and tissue engineering are the current research interests of the scientific fraternity. Here we attempt to review the literature on zein as a biopolymer for drug/vaccine/gene delivery and its applicability in tissue engineering.
将生物活性物质递送到特定的器官、细胞和亚细胞水平是药物载体系统的理想特性。为了实现这一目标，制剂科学家正在寻找更好的生物材料替代品，以便更精确、更可控地在体内输送治疗药物。玉米醇溶蛋白是一种植物蛋白，可用于农业、化妆品、包装和制药等多个工业领域。由于它是一种疏水蛋白，具有生物降解性、生物相容性、经济实用且被普遍认为是安全的“GRAS”状态，因此它是一种很有吸引力的用于人体的生物材料。玉米醇溶蛋白的新型生物医学应用，如生物活性物质的控制和靶向递送以及组织工程，是科学界目前的研究热点。在这里，我们尝试综述关于玉米醇溶蛋白作为药物/疫苗/基因递送的生物聚合物及其在组织工程中的应用的文献。
