高通量筛选在生物材料发现中的应用。
High throughput screening for biomaterials discovery.
机构信息
Laboratory of Biophysics and Surface Analysis, School of Pharmacy, The University of Nottingham, Nottingham, NG7 2RD, UK.
Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 45 Carleton Street, Building E25-342, Cambridge, MA 02142, USA; Harvard-MIT Division of Health Science Technology, Massachusetts Institute of Technology, 45 Carleton Street, Building E25-342, Cambridge, MA 02142, USA.
出版信息
J Control Release. 2014 Sep 28;190:115-26. doi: 10.1016/j.jconrel.2014.06.045. Epub 2014 Jun 30.
Using microarray technologies thousands of biomedical materials can be screened in a rapid, parallel and cost effective fashion to identify the optimum candidate that fulfils a specific biomedical application. High throughput surface characterization (HTSC) of printed microarrays has played a key role in the discovery and development of biomedical materials. This review focuses on the production and HTSC of microarrays, their application in specific biomedical fields and a future perspective on the development of this technology.
利用微阵列技术，可以快速、平行且经济有效地筛选数千种生物医学材料，以确定满足特定生物医学应用的最佳候选物。印刷微阵列的高通量表面特性化（HTSC）在生物医学材料的发现和开发中发挥了关键作用。本文重点介绍了微阵列的制作和 HTSC、它们在特定生物医学领域的应用以及该技术发展的未来展望。
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