Zhou Peipei, He Jinxu, Huang Lu, Yu Ziming, Su Zhenning, Shi Xuetao, Zhou Jianhua
Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou 510006, China.
School of Mechatronic Engineering, Guangdong Polytechnic Normal University, Guangzhou 510665, China.
Nanomaterials (Basel). 2020 Dec 15;10(12):2514. doi: 10.3390/nano10122514.
High-throughput screening is a potent technique to accelerate the discovery and development of new materials. By performing massive synthesis and characterization processes in parallel, it can rapidly discover materials with desired components, structures and functions. Among the various approaches for high-throughput screening, microfluidic platforms have attracted increasing attention. Compared with many current strategies that are generally based on robotic dispensers and automatic microplates, microfluidic platforms can significantly increase the throughput and reduce the consumption of reagents by several orders of magnitude. In this review, we first introduce current advances of the two types of microfluidic high-throughput platforms based on microarrays and microdroplets, respectively. Then the utilization of these platforms for screening different types of materials, including inorganic metals, metal alloys and organic polymers are described in detail. Finally, the challenges and opportunities in this promising field are critically discussed.
高通量筛选是加速新型材料发现与开发的一项强大技术。通过并行执行大规模合成和表征过程，它能够快速发现具有所需成分、结构和功能的材料。在高通量筛选的各种方法中，微流控平台已引起越来越多的关注。与目前许多通常基于机器人分配器和自动微孔板的策略相比，微流控平台可以显著提高通量，并将试剂消耗降低几个数量级。在本综述中，我们首先分别介绍基于微阵列和微滴的两种微流控高通量平台的当前进展。然后详细描述这些平台在筛选不同类型材料（包括无机金属、金属合金和有机聚合物）方面的应用。最后，对这一充满前景的领域中的挑战和机遇进行了批判性讨论。
