Collignon Anne-Margaux, Lesieur Julie, Vacher Christian, Chaussain Catherine, Rochefort Gael Y
EA 2496 Orofacial Pathologies, Imaging and Biotherapies, Dental School Faculty, Life Imaging Platform (PIV), University Paris Descartes, Montrouge, France.
Department of Odontology, University Hospitals PNVS, Assistance Publique Hopitaux De Paris, Paris, France.
Front Physiol. 2017 Nov 14;8:927. doi: 10.3389/fphys.2017.00927. eCollection 2017.
Bone exhibits a great ability for endogenous self-healing. Nevertheless, impaired bone regeneration and healing is on the rise due to population aging, increasing incidence of bone trauma and the clinical need for the development of alternative options to autologous bone grafts. Current strategies, including several biomolecules, cellular therapies, biomaterials, and different permutations of these, are now developed to facilitate the vascularization and the engraftment of the constructs, to recreate ultimately a bone tissue with the same properties and characteristics of the native bone. In this review, we browse the existing strategies that are currently developed, using biomolecules, cells and biomaterials, to induce, direct and potentiate bone healing after injury and further discuss the biological processes associated with this repair.
骨骼具有很强的内源性自我修复能力。然而，由于人口老龄化、骨创伤发病率不断上升以及临床上对自体骨移植替代方案的需求，骨再生和愈合受损的情况正在增加。目前已开发出多种策略，包括几种生物分子、细胞疗法、生物材料以及它们的不同组合，以促进构建体的血管化和植入，最终重建具有与天然骨相同特性和特征的骨组织。在本综述中，我们浏览了目前正在开发的利用生物分子、细胞和生物材料诱导、引导和增强损伤后骨愈合的现有策略，并进一步讨论与此修复相关的生物学过程。
