Tielemans S M A J, Kromhout D, Altorf-van der Kuil W, Geleijnse J M
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands; Top Institute Food and Nutrition, Wageningen, The Netherlands.
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
Nutr Metab Cardiovasc Dis. 2014 Nov;24(11):1228-33. doi: 10.1016/j.numecd.2014.05.013. Epub 2014 Jun 9.
The aim of the present study was to investigate the association of plant and animal protein intake with 5-year changes in blood pressure (BP) level.
Analyses were based on 702 observations of 272 men participating in the Zutphen Elderly Study. Men did not use antihypertensive medication and were initially free of cardiovascular disease, diabetes mellitus and cancer. Physical and dietary examinations were performed in 1985, 1990, 1995, and 2000. Diet was assessed using the cross-check dietary history method. Men were categorised into tertiles according to their plant and animal protein intake. BP was measured twice at each examination. The associations of plant and animal protein intake with 5-year changes in BP level were investigated by a random intercept model with first-order autoregressive (AR [1]) serial correlation and a nugget effect. Adjustments were made for age, examination year, BMI, socioeconomic status, smoking, physical activity, prescribed diet, alcohol consumption and intake of energy and nutrients. In 1985, men were 70.1 ± 4.6 years old and had a mean BP of 147/84 mmHg. Mean protein intake was 15 en%, of which one-third consisted of plant protein. The higher-intake tertiles of plant protein intake were associated with a mean 5-year change of -2.9 mmHg (95% CI: -5.6, -0.2) systolic and -1.7 mmHg (95% CI: -3.2, -0.2) diastolic, compared with the lowest-intake tertile. No associations were observed for animal protein intake.
Intake of plant protein, but not animal protein, was inversely associated with 5-year changes in BP level in elderly men.
本研究旨在调查植物蛋白和动物蛋白摄入量与血压（BP）水平5年变化之间的关联。
分析基于祖特芬老年研究中272名男性的702次观察数据。这些男性未使用抗高血压药物，最初无心血管疾病、糖尿病和癌症。在1985年、1990年、1995年和2000年进行了身体和饮食检查。饮食采用交叉核对饮食史方法进行评估。根据植物蛋白和动物蛋白摄入量将男性分为三个三分位数组。每次检查时测量两次血压。采用具有一阶自回归（AR[1]）序列相关性和块金效应的随机截距模型研究植物蛋白和动物蛋白摄入量与血压水平5年变化之间的关联。对年龄、检查年份、体重指数、社会经济地位、吸烟、身体活动、规定饮食、酒精消费以及能量和营养素摄入量进行了调整。1985年，男性年龄为70.1±4.6岁，平均血压为147/84 mmHg。平均蛋白质摄入量为15能量百分比，其中三分之一为植物蛋白。与最低摄入量三分位数组相比，植物蛋白摄入量较高的三分位数组收缩压平均5年变化为-2.9 mmHg（95%CI：-5.6，-0.2），舒张压平均5年变化为-1.7 mmHg（95%CI：-3.2，-0.2）。未观察到动物蛋白摄入量与血压变化之间的关联。
在老年男性中，植物蛋白摄入量与血压水平的5年变化呈负相关，而动物蛋白摄入量与血压水平的5年变化无关联。
