Patruno Cataldo, Ayala Fabio, Zagaria Orlando, Balato Nicola
From the Dipartimento di Medicina clinica e Chirurgia, Sezione di Dermatologia, Università di Napoli Federico II, Napoli, Italy.
Dermatitis. 2014 Jul-Aug;25(4):201-4. doi: 10.1097/DER.0000000000000054.
Chronic hand eczema is defined as a persistent (>6 months' duration) noninfectious skin inflammation of the hands. It is twice as common in women as men. Although genetic factors have been considered, greater exposure of women to wet work, such as housework, is assumed to be the most likely explanation. It has been debated whether lifestyle factors may be associated with chronic hand eczema.
The objective of this study was to evaluate the influence of cigarette smoking on housewives for the development of chronic hand eczema.
We analyzed 516 housewives 18 years or older. Two hundred fourteen were affected by chronic hand eczema, and 302 were control subjects. Both patients and control subjects were divided into 2 subgroups, smokers and nonsmokers. An anonymous questionnaire was submitted to each woman.
No significant differences emerged between "smokers" and "nonsmokers" concerning the incidence of chronic hand eczema. In addition, the smokers were mainly affected by a milder ("almost clear") form of the disease. On the other hand, "severe" forms of chronic hand eczema might be more frequent in nonsmokers when compared with smokers. This study suggests that smoking is not associated with onset of chronic hand eczema, but with less severe chronic hand eczema.
慢性手部湿疹被定义为手部持续（病程>6个月）的非感染性皮肤炎症。女性的发病率是男性的两倍。尽管遗传因素已被考虑在内，但女性更多地从事如家务等湿作业被认为是最可能的解释。生活方式因素是否与慢性手部湿疹有关一直存在争议。
本研究的目的是评估吸烟对家庭主妇患慢性手部湿疹的影响。
我们分析了516名18岁及以上的家庭主妇。其中214人患有慢性手部湿疹，302人为对照对象。患者和对照对象均分为两个亚组，吸烟者和非吸烟者。向每位女性发放了一份匿名问卷。
“吸烟者”和“非吸烟者”在慢性手部湿疹发病率方面没有显著差异。此外，吸烟者主要患的是病情较轻（“几乎痊愈”）的疾病形式。另一方面，与吸烟者相比，非吸烟者中“重度”慢性手部湿疹可能更常见。这项研究表明，吸烟与慢性手部湿疹的发病无关，但与病情较轻的慢性手部湿疹有关。
