Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10720-5. doi: 10.1073/pnas.1319641111. Epub 2014 Jul 7.
There is enduring interest in why some of us have clearer memories than others, given the substantial individual variation that exists in retrieval ability and the precision with which we can differentiate past experiences. Here we report novel evidence showing that variation in the size of human hippocampal subfield CA3 predicted the amount of neural interference between episodic memories within CA3, which in turn predicted how much retrieval confusion occurred between past memories. This effect was not apparent in other hippocampal subfields. This shows that subtle individual differences in subjective mnemonic experience can be accurately gauged from measurable variations in the anatomy and neural coding of hippocampal region CA3. Moreover, this mechanism may be relevant for understanding memory muddles in aging and pathological states.
鉴于在检索能力和我们区分过去经验的准确性方面存在着巨大的个体差异，人们一直对为什么我们中的一些人拥有比其他人更清晰的记忆感到好奇。在这里，我们报告了新的证据，表明人类海马旁回 CA3 体积的变化预测了 CA3 内情景记忆之间的神经干扰程度，进而预测了过去记忆之间发生的检索混淆程度。这一效应在其他海马旁回中并不明显。这表明，从海马区 CA3 的解剖结构和神经编码的可测量变化中，可以准确地衡量主观记忆体验的细微个体差异。此外，该机制可能与理解衰老和病理状态下的记忆混乱有关。
