Milic-Emili J
Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
Lung. 1989;167(3):141-8. doi: 10.1007/BF02714943.
In the past it has been generally assumed that pulmonary flow resistance (RL) increases with increasing flow and decreases with increasing lung volume. Recent work indicates that RL decreases with increasing flow, at least up to flow rates 3-4 times greater than those at rest, and increases progressively with increasing lung volume. This behaviour results mainly from dynamic pressure dissipations within the pulmonary tissues due to viscoelastic phenomena. In fact, during resting breathing the contribution of the latter to RL is more important than that of airway resistance.
过去人们普遍认为肺血流阻力(RL)随流量增加而增加,随肺容积增加而降低。最近的研究表明,RL随流量增加而降低,至少在流量比静息时大3至4倍之前是这样,并且随肺容积增加而逐渐增加。这种现象主要是由于粘弹性现象导致肺组织内的动态压力耗散。事实上,在静息呼吸时,后者对RL的贡献比气道阻力的贡献更重要。