Singh Keerti, Krishnamurthy Kandamaran, Greaves Camille, Kandamaran Latha, Nielsen Anders L, Kumar Alok
Faculty of Medical Sciences, University of the West Indies, Cave Hill, BB23034, Barbados.
The Queen Elizabeth Hospital, Martindales Road, Street Michael, BB14018, Barbados.
ISRN Obstet Gynecol. 2014 Apr 6;2014:651783. doi: 10.1155/2014/651783. eCollection 2014.
Objectives. To study the prevalence and the pattern of major congenital malformations and its contribution to the overall perinatal morbidity and mortality. Methods. It is a retrospective population based study. It includes all major congenital malformations in newborns during 1993-2012. The data was collected from the birth register, the neonatal admission register and the individual patient records at the Queen Elizabeth Hospital where over 90% of deliveries take place and it is the only facility for the care of sick newborns in this country. Results. The overall prevalence of major congenital malformations among the live births was 59/10,000 live births and that among the stillbirths was 399/10,000 stillbirths. Circulatory system was the most commonly affected and accounted for 20% of all the major congenital malformations. Individually, Down syndrome (4.1/10, 000 live births) was the commonest major congenital malformation. There was a significant increase in the overall prevalence during the study period. Major congenital malformations were responsible for 14% of all neonatal death. Conclusions. Less than 1% of all live newborns have major congenital malformations with a preponderance of the malformations of the circulatory system. Major congenital malformations contribute significantly to the overall neonatal morbidity and mortality in this country.
目的。研究主要先天性畸形的患病率及模式，及其对围产期总体发病率和死亡率的影响。方法。这是一项基于人群的回顾性研究。研究对象包括1993年至2012年期间新生儿中的所有主要先天性畸形。数据收集自出生登记册、新生儿入院登记册以及伊丽莎白女王医院的个体患者记录，该医院承担了该国90%以上的分娩，且是该国唯一一家照顾患病新生儿的机构。结果。活产儿中主要先天性畸形的总体患病率为59/10000活产儿，死产儿中为399/10000死产儿。循环系统是最常受影响的系统，占所有主要先天性畸形的20%。单就个体而言，唐氏综合征（4.1/10000活产儿）是最常见的主要先天性畸形。在研究期间，总体患病率显著上升。主要先天性畸形占所有新生儿死亡的14%。结论。所有存活新生儿中，不到1%患有主要先天性畸形，其中循环系统畸形占多数。主要先天性畸形对该国新生儿的总体发病率和死亡率有显著影响。
