两种新型细胞松弛素——硬柄黑粉菌素A和B的分离、结构分析及其对慢性淋巴细胞白血病的生物活性测定
Isolation, structural analyses and biological activity assays against chronic lymphocytic leukemia of two novel cytochalasins - sclerotionigrin A and B.
作者信息
Petersen Lene M, Bladt Tanja T, Dürr Claudia, Seiffert Martina, Frisvad Jens C, Gotfredsen Charlotte H, Larsen Thomas O
机构信息
Department of Systems Biology, Technical University of Denmark, Søltofts Plads B221, DK-2800 Kgs. Lyngby, Denmark.
German Cancer Research Center, Molecular Genetics, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
出版信息
Molecules. 2014 Jul 8;19(7):9786-97. doi: 10.3390/molecules19079786.
Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active.
从丝状真菌黑曲霉中分离出了两种新的细胞松弛素，即硬皮黑菌素A（1）和B（2），同时还分离出了已知的原间霉素（3）。通过与3进行比较，并结合广泛的一维和二维核磁共振光谱分析，以及高分辨率质谱（HRMS）的支持，确定了1和2的结构及相对立体化学。化合物2和3在体外对慢性淋巴细胞白血病细胞显示出细胞毒性活性，其中3的活性最强。
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