Stevens J, Khetarpal S
Northeast Ohio Medical University, Rootstown, Ohio.
Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio.
Int J Womens Dermatol. 2018 Sep 21;5(1):46-51. doi: 10.1016/j.ijwd.2018.08.004. eCollection 2019 Feb.
Androgenetic alopecia (AGA) is a common hair loss disorder caused by genetic and hormonal factors that are characterized by androgen-related progressive thinning of scalp hair in a defined pattern. By the age of 60 years, 45% of men and 35% of women develop AGA. Currently, U.S. Food and Drug Administration-approved treatments for AGA include oral finasteride and topical minoxidil. Due to the limited number of effective therapies for AGA, platelet-rich plasma (PRP) has become an effective alternative treatment. PRP is an autologous concentration of platelets in plasma with numerous growth factors that contribute to hair regeneration. The growth factors contained within the alpha granules of platelets act on stem cells in the bulge area of the hair follicles and stimulate the development of new follicles along with neovascularization. PRP has become a promising treatment modality for AGA. Although there have been several studies previously reported, a standard practice for PRP preparation and administration as well as a method to evaluate results have not been established. This literature review was conducted to evaluate the effectiveness of PRP for AGA and discuss the various treatment protocols that have been proposed.
雄激素性脱发（AGA）是一种常见的脱发疾病，由遗传和激素因素引起，其特征是头皮毛发以特定模式出现与雄激素相关的渐进性变薄。到60岁时，45%的男性和35%的女性会患上AGA。目前，美国食品药品监督管理局批准的AGA治疗方法包括口服非那雄胺和外用米诺地尔。由于AGA的有效治疗方法数量有限，富含血小板血浆（PRP）已成为一种有效的替代治疗方法。PRP是血浆中血小板的自体浓缩物，含有多种有助于头发生长的生长因子。血小板α颗粒中所含的生长因子作用于毛囊隆突区的干细胞，并刺激新毛囊的发育以及新血管形成。PRP已成为AGA一种有前景的治疗方式。尽管此前已有多项研究报道，但PRP的制备和给药标准方法以及评估结果的方法尚未确立。进行这项文献综述是为了评估PRP治疗AGA的有效性，并讨论已提出的各种治疗方案。
