Tashnizi Mohammad Abbasi, Alamdari Daryoush Hamidi, Khayami Mohammad Esmail, Rahimi Hamid Reza, Moeinipour Aliasghar, Amouzeshi Ahmad, Seifalian Alexander M
Department of Cardiac Surgery, Imam Reza Academic Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Stem cell and Regenerative Medicine Research Group, Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Indian J Plast Surg. 2013 Sep;46(3):538-42. doi: 10.4103/0970-0358.122011.
Non-healing wound in the sternal region after coronary arteries bypass graft surgery is a serious complication. For healing a chronic wound, several novel approaches have been proposed recently such as using bone marrow stem cells, platelets and fibrin glue (PFG); but a non-invasive method is highly desirable in the first approach for treatment. The current study was undertaken to evaluate the effect of the combination of PFG in one treatment.
We report on the treatment of six patients with life-threatening chronic sternum wounds, which caused septicemia with multi-drug resistant pathogens. The ulcers were extensively debrided initially and were measured and photographed at weekly intervals. The combination of PFG was applied topically on the wound after every 2 days.
The wounds were completely closed in five patients and significantly reduced in size in one. There was no evidence of local or systemic complications and any abnormal tissue formation, keloid or hypertrophic scarring.
Our study suggests, in the first approach, PFG can be used safely in order to heal a non healing sternum wound following coronary artery bypass surgery.
冠状动脉搭桥手术后胸骨区域伤口不愈合是一种严重的并发症。对于慢性伤口的愈合，最近提出了几种新方法，如使用骨髓干细胞、血小板和纤维蛋白胶（PFG）；但在第一种治疗方法中，非常需要一种非侵入性方法。本研究旨在评估PFG联合治疗的效果。
我们报告了6例患有危及生命的慢性胸骨伤口患者的治疗情况，这些伤口由多重耐药病原体引起败血症。最初对溃疡进行广泛清创，并每周进行测量和拍照。每2天在伤口局部应用一次PFG联合制剂。
5例患者伤口完全愈合，1例患者伤口大小显著减小。没有局部或全身并发症以及任何异常组织形成、瘢痕疙瘩或肥厚性瘢痕的证据。
我们的研究表明，在第一种治疗方法中，PFG可安全用于治疗冠状动脉搭桥手术后胸骨不愈合伤口。
