鞣花酸的抗癌作用及机制研究进展。
Research progress on the anticarcinogenic actions and mechanisms of ellagic acid.
机构信息
1 Medical Sciences Research Center, 2 Department of Pharmacy, The Second Affiliated Hospital of Southeast University, Nanjing 210003, China ; 3 Nanjing Longyuan Natural Polyphenol Synthesis Institute, Nanjing 210042, China.
出版信息
Cancer Biol Med. 2014 Jun;11(2):92-100. doi: 10.7497/j.issn.2095-3941.2014.02.004.
Abstract
Cancer is a leading cause of death worldwide. Cancer treatments by chemotherapeutic agents, surgery, and radiation have not been highly effective in reducing the incidence of cancers and increasing the survival rate of cancer patients. In recent years, plant-derived compounds have attracted considerable attention as alternative cancer remedies for enhancing cancer prevention and treatment because of their low toxicities, low costs, and low side effects. Ellagic acid (EA) is a natural phenolic constituent. Recent in vitro and in vivo experiments have revealed that EA elicits anticarcinogenic effects by inhibiting tumor cell proliferation, inducing apoptosis, breaking DNA binding to carcinogens, blocking virus infection, and disturbing inflammation, angiogenesis, and drug-resistance processes required for tumor growth and metastasis. This review enumerates the anticarcinogenic actions and mechanisms of EA. It also discusses future directions on the applications of EA.
摘要
癌症是全球主要死因之一。化疗药物、手术和放疗在降低癌症发病率和提高癌症患者生存率方面的效果并不显著。近年来，植物衍生化合物因其低毒性、低成本和低副作用而备受关注，成为癌症治疗的替代方法，以增强癌症的预防和治疗效果。鞣花酸 (EA) 是一种天然的酚类成分。最近的体外和体内实验表明，EA 通过抑制肿瘤细胞增殖、诱导细胞凋亡、破坏 DNA 与致癌物的结合、阻断病毒感染以及干扰肿瘤生长和转移所需的炎症、血管生成和耐药过程，发挥抗癌作用。本文列举了 EA 的抗癌作用和机制，并讨论了 EA 的应用前景。
相似文献
1
Research progress on the anticarcinogenic actions and mechanisms of ellagic acid.鞣花酸的抗癌作用及机制研究进展。
Cancer Biol Med. 2014 Jun;11(2):92-100. doi: 10.7497/j.issn.2095-3941.2014.02.004.
2
Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence.鞣花酸与癌症标志：来自实验证据的见解。
Biomolecules. 2023 Nov 15;13(11):1653. doi: 10.3390/biom13111653.
3
Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions.探索鞣花酸在预防胃肠道癌症方面的潜力：最新进展与未来方向
Oncol Ther. 2024 Dec;12(4):685-699. doi: 10.1007/s40487-024-00296-1. Epub 2024 Sep 2.
4
Ellagic acid binding to DNA as a possible mechanism for its antimutagenic and anticarcinogenic action.鞣花酸与DNA结合作为其抗诱变和抗癌作用的一种可能机制。
Cancer Lett. 1986 Mar;30(3):329-36. doi: 10.1016/0304-3835(86)90058-3.
5
Multiple effects of ellagic acid on human colorectal carcinoma cells identified by gene expression profile analysis.通过基因表达谱分析鉴定出鞣花酸对人结肠癌细胞的多种作用。
Int J Oncol. 2017 Feb;50(2):613-621. doi: 10.3892/ijo.2017.3843. Epub 2017 Jan 5.
6
Organ specific, protocol dependent modulation of 7,12-dimethylbenz[a]anthracene carcinogenesis in rainbow trout (Oncorhynchus mykiss) by dietary ellagic acid.膳食鞣花酸对虹鳟（Oncorhynchus mykiss）中7,12-二甲基苯并[a]蒽致癌作用的器官特异性、方案依赖性调节。
Carcinogenesis. 1996 Nov;17(11):2403-9. doi: 10.1093/carcin/17.11.2403.
7
Ellagic acid, sulforaphane, and ursolic acid in the prevention and therapy of breast cancer: current evidence and future perspectives.鞣花酸、萝卜硫素和熊果酸在乳腺癌的预防和治疗中的作用：当前的证据和未来的展望。
Breast Cancer. 2018 Sep;25(5):517-528. doi: 10.1007/s12282-018-0866-4. Epub 2018 May 3.
8
Ellagic Acid Inhibits Bladder Cancer Invasiveness and In Vivo Tumor Growth.鞣花酸抑制膀胱癌侵袭及体内肿瘤生长。
Nutrients. 2016 Nov 22;8(11):744. doi: 10.3390/nu8110744.
9
Gallic and ellagic acids: two natural immunomodulator compounds solve infection of macrophages by Leishmania major.没食子酸和鞣花酸：两种天然免疫调节剂化合物可解决巨噬细胞感染利什曼原虫的问题。
Naunyn Schmiedebergs Arch Pharmacol. 2017 Sep;390(9):893-903. doi: 10.1007/s00210-017-1387-y. Epub 2017 Jun 22.
10
Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice.鞣花酸抑制 Balb c 裸鼠人胰腺癌细胞生长。
Cancer Lett. 2013 Sep 1;337(2):210-7. doi: 10.1016/j.canlet.2013.05.009. Epub 2013 May 16.
引用本文的文献
1
Unveiling a novel ellagic acid derivative as a potent lipoxygenase (LOX) inhibitor: integration of computational modeling and experimental validation.揭示一种新型鞣花酸衍生物作为一种有效的脂氧合酶（LOX）抑制剂：计算建模与实验验证的整合。
J Comput Aided Mol Des. 2025 Jul 5;39(1):42. doi: 10.1007/s10822-025-00618-z.
2
Regulation of Matrix Metalloproteinases by Wine-Derived Compounds: Implications for Cancer Therapy.葡萄酒衍生化合物对基质金属蛋白酶的调节作用：对癌症治疗的启示
Biomolecules. 2025 May 28;15(6):781. doi: 10.3390/biom15060781.
3
Ellagic acid suppresses the human renal carcinoma cell migration and invasion by targeting the RUNX2/MMP1 expression.鞣花酸通过靶向RUNX2/MMP1表达抑制人肾癌细胞的迁移和侵袭。
Int J Med Sci. 2025 Apr 22;22(10):2308-2317. doi: 10.7150/ijms.112117. eCollection 2025.
4
Genome-Wide Identification and Expression Profiling of Glycosidases, Lipases, and Proteases from Invasive Asian Palm Weevil, .亚洲入侵性棕榈象甲糖苷酶、脂肪酶和蛋白酶的全基因组鉴定及表达谱分析
Insects. 2025 Apr 17;16(4):421. doi: 10.3390/insects16040421.
5
Herbal nanoparticles: bridging traditional medicine and modern science in epilepsy treatment.草药纳米颗粒：在癫痫治疗中架起传统医学与现代科学的桥梁。
Naunyn Schmiedebergs Arch Pharmacol. 2025 May 7. doi: 10.1007/s00210-025-04239-z.
6
Eugenia brasiliensis: Analysis of the Chemical Profile and Evaluation of Cytotoxic Potential.巴西番樱桃：化学特征分析及细胞毒性潜力评估
Chem Biodivers. 2025 Sep;22(9):e202500429. doi: 10.1002/cbdv.202500429. Epub 2025 May 1.
7
A novel cobalt oxide nanoparticle conjugated with ellagic acid arrests the cell cycle in human liver cancer cell line.一种与鞣花酸结合的新型氧化钴纳米颗粒可使人类肝癌细胞系的细胞周期停滞。
Sci Rep. 2025 Jan 13;15(1):1797. doi: 10.1038/s41598-025-85312-8.
8
The Therapeutic Effects of Bioactive Compounds on Colorectal Cancer via PI3K/Akt/mTOR Signaling Pathway: A Critical Review.生物活性化合物通过PI3K/Akt/mTOR信号通路对结直肠癌的治疗作用：一项综述
Food Sci Nutr. 2024 Nov 7;12(12):9951-9973. doi: 10.1002/fsn3.4534. eCollection 2024 Dec.
9
Ellagic Acid Induces DNA Damage and Apoptosis in Cancer Stem-like Cells and Overcomes Cisplatin Resistance.鞣花酸诱导癌症干细胞样细胞中的DNA损伤和细胞凋亡并克服顺铂耐药性。
ACS Omega. 2024 Dec 5;9(50):48988-49000. doi: 10.1021/acsomega.3c08819. eCollection 2024 Dec 17.
10
A recent update on the connection between dietary phytochemicals and skin cancer: emerging understanding of the molecular mechanism.饮食中的植物化学物质与皮肤癌之间联系的最新进展：对分子机制的新认识
Ann Med Surg (Lond). 2024 Aug 7;86(10):5877-5913. doi: 10.1097/MS9.0000000000002392. eCollection 2024 Oct.
本文引用的文献
1
Ellagic acid induces novel and atypical PKC isoforms and promotes caspase-3 dependent apoptosis by blocking energy metabolism.鞣花酸可诱导新型非典型蛋白激酶C亚型，并通过阻断能量代谢促进半胱天冬酶-3依赖性凋亡。
Nutr Cancer. 2014;66(4):675-81. doi: 10.1080/01635581.2013.878735. Epub 2014 Feb 26.
2
Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells.鞣花酸和杨梅素影响胰腺腺癌、癌症和星状细胞的关键细胞成分。
Nutr Cancer. 2013;65(8):1232-44. doi: 10.1080/01635581.2013.832779. Epub 2013 Oct 15.
3
Apoptotic markers in a prostate cancer cell line: effect of ellagic acid.前列腺癌细胞系中的凋亡标记物：鞣花酸的影响。
Oncol Rep. 2013 Dec;30(6):2804-10. doi: 10.3892/or.2013.2757. Epub 2013 Sep 30.
4
Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells.Ⅱ相代谢限制了尿石素在人结肠癌细胞中的抗增殖活性。
Eur J Nutr. 2014 Apr;53(3):853-64. doi: 10.1007/s00394-013-0589-4.
5
Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence.敌友之间：活化B细胞核因子κ轻链增强子在细胞衰老中的新作用
Onco Targets Ther. 2013 Sep 4;6:1221-9. doi: 10.2147/OTT.S36160.
6
The inhibitory effect of ellagic Acid on cell growth of ovarian carcinoma cells.鞣花酸对卵巢癌细胞生长的抑制作用。
Evid Based Complement Alternat Med. 2013;2013:306705. doi: 10.1155/2013/306705. Epub 2013 Jun 16.
7
Ellagic acid inhibits migration and invasion by prostate cancer cell lines.鞣花酸可抑制前列腺癌细胞系的迁移和侵袭。
Asian Pac J Cancer Prev. 2013;14(5):2859-63. doi: 10.7314/apjcp.2013.14.5.2859.
8
Biological significance of urolithins, the gut microbial ellagic Acid-derived metabolites: the evidence so far.乌洛托品，肠道微生物鞣花酸衍生代谢物的生物学意义：迄今为止的证据。
Evid Based Complement Alternat Med. 2013;2013:270418. doi: 10.1155/2013/270418. Epub 2013 May 28.
9
Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis.石榴汁代谢物、鞣花酸和乌索酸通过对细胞周期控制和细胞凋亡的不同作用协同抑制雄激素非依赖性前列腺癌细胞生长。
Evid Based Complement Alternat Med. 2013;2013:247504. doi: 10.1155/2013/247504. Epub 2013 Apr 24.
10
Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice.鞣花酸抑制 Balb c 裸鼠人胰腺癌细胞生长。
Cancer Lett. 2013 Sep 1;337(2):210-7. doi: 10.1016/j.canlet.2013.05.009. Epub 2013 May 16.
Zotero 插件