用于光学相干断层扫描的纳米级造影剂工程
Engineering of Nanoscale Contrast Agents for Optical Coherence Tomography.
作者信息
Gordon Andrew Y, Jayagopal Ashwath
机构信息
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, USA.
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, USA ; Vanderbilt Eye Institute, Vanderbilt University Medical Center, USA.
出版信息
J Nanomed Nanotechnol. 2014 Jan 30;Suppl 5:004. doi: 10.4172/2157-7439.S5-004.
Optical coherence tomography has emerged as valuable imaging modalityin ophthalmology and other fields by enabling high-resolution three-dimensional imaging of tissue. In this paper, we review recent progress in the field of contrast-enhanced optical coherence tomography (OCT). We discuss exogenous and endogenous sources of OCT contrast, focusing on their use with standard OCT systems as well as emerging OCT-based imaging modalities. We include advances in the processing of OCT data that generate improved tissue contrast, including spectroscopic OCT (SOCT), as well as work utilizing secondary light sources and/or detection mechanisms to create and detect enhanced contrast, including photothermal OCT (PTOCT) and photoacoustic OCT (PAOCT). Finally, we conclude with a discussion of the translational potential of these developments as well as barriers to their clinical use.
光学相干断层扫描已成为眼科及其他领域中一种重要的成像方式，它能够实现对组织的高分辨率三维成像。在本文中，我们回顾了对比增强光学相干断层扫描（OCT）领域的最新进展。我们讨论了OCT对比的外源性和内源性来源，重点关注它们在标准OCT系统中的应用以及新兴的基于OCT的成像方式。我们涵盖了在OCT数据处理方面取得的进展，这些进展可产生更好的组织对比度，包括光谱OCT（SOCT），以及利用二次光源和/或检测机制来产生和检测增强对比度的工作，包括光热OCT（PTOCT）和光声OCT（PAOCT）。最后，我们讨论了这些进展的转化潜力以及它们在临床应用中的障碍。
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