Fernandez-Gonzalo Sol, Jodar Merce, Pousa Esther, Turon Marc, Garcia Rebeca, Rambla Carla Hernandez, Palao Diego
*Research Department, Foundation Parc Taulí, Universitary Institute, Universitat Autònoma de Barcelona, Parc Taulí Sabadell, Universitary Hospital, Sabadell; †Department of Clinical and Health Psychology, Psychopathology and Neuropsychology Research Unit, Universitat Autònoma de Barcelona, Bellaterra; ‡Neurology Department Parc Taulí, Sabadell, University Hospital-Universitat Autònoma de Barcelona, Bellaterra; §Mental Health Department, Parc Taulí, Sabadell, University Hospital-Universitat Autònoma de Barcelona, Bellaterra; and ∥Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.
J Nerv Ment Dis. 2014 Aug;202(8):576-82. doi: 10.1097/NMD.0000000000000164.
The aim of this study was to investigate the influence of neurocognition on affective and cognitive theory of mind (ToM) tasks in early phases of psychosis. In a cross-sectional study of 60 first-episode schizophrenia/schizoaffective disorder patients, the implication of neurocognition in first- and second-order ToM stories, Hinting Task, and Reading the Mind in the Eyes Test (RMET) was analyzed. Regression models were used, controlling for clinical symptoms and antipsychotic dose. Spatial span backward (odds ratio [OR], 0.34; p = 0.01) and intrusions in the Rey Auditory Verbal Learning Test (OR, 4.86; p = 0.04) were the best factors to predict second-order ToM failure. Trail Making Test B (B = 0.01; p = 0.04) and negative symptoms (B = 0.09; p = 0.01) predicted Hinting task performance while Block design (B = 0.1; p = 0.04) was related to RMET outcome. Executive functions and clinical symptoms were related to ToM performance in first-episode schizophrenia patients, although different patterns of relationship were observed in each ToM task.
本研究旨在调查神经认知对精神病早期阶段情感和认知心理理论（ToM）任务的影响。在一项对60例首发精神分裂症/分裂情感性障碍患者的横断面研究中，分析了神经认知在一阶和二阶ToM故事、提示任务以及眼睛解读心智测验（RMET）中的作用。使用回归模型，控制临床症状和抗精神病药物剂量。反向空间广度（优势比[OR]，0.34；p = 0.01）和雷伊听觉词语学习测验中的侵入错误（OR，4.86；p = 0.04）是预测二阶ToM失败的最佳因素。连线测验B（B = 0.01；p = 0.04）和阴性症状（B = 0.09；p = 0.01）可预测提示任务表现，而积木设计（B = 0.1；p = 0.04）与RMET结果相关。在首发精神分裂症患者中，执行功能和临床症状与ToM表现相关，尽管在每个ToM任务中观察到不同的关系模式。
