糖尿病可能通过降低神经可塑性诱发心血管疾病。
Diabetes mellitus may induce cardiovascular disease by decreasing neuroplasticity.
作者信息
Zheng Zhihua, Wu Junyan, Wang Ruolun, Zeng Yingtong
出版信息
Funct Neurol. 2014 Jan-Mar;29(1):7-13.
Abstract
Neuroplasticity has been defined "the ability of the nervous system to respond to intrinsic or extrinsic stimuli by reorganizing its structure, function and connections". The nervous system monitors and coordinates internal organ function. Thus neuroplasticity may be associated with the pathogenesis of other diseases besides neuropsychiatric diseases. Decreased neuroplasticity is associated with cardiovascular disease (CVD) and a disease related to decreased neuroplasticity may confer a greater CVD risk. Diabetes mellitus (DM) is related to CVD and DM induces decreased neuroplasticity, which is manifested as depression, Alzheimer's disease and diabetic neuropathy. Therefore we conclude that DM may induce CVD by decreasing neuroplasticity.
摘要
神经可塑性被定义为“神经系统通过重组其结构、功能和连接来响应内在或外在刺激的能力”。神经系统监测并协调内脏器官功能。因此，神经可塑性可能与除神经精神疾病之外的其他疾病的发病机制相关。神经可塑性降低与心血管疾病（CVD）相关，而一种与神经可塑性降低相关的疾病可能会带来更高的CVD风险。糖尿病（DM）与CVD相关，且DM会导致神经可塑性降低，表现为抑郁、阿尔茨海默病和糖尿病性神经病变。因此我们得出结论，DM可能通过降低神经可塑性来诱发CVD。
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