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红肉和加工肉类的消费与肺癌风险:对33项已发表研究的剂量反应荟萃分析。

Red and processed meat consumption and the risk of lung cancer: a dose-response meta-analysis of 33 published studies.

作者信息

Xue Xiu-Juan, Gao Qing, Qiao Jian-Hong, Zhang Jie, Xu Cui-Ping, Liu Ju

机构信息

Qianfoshan Hospital, Shandong University Jinan, China.

Taishan Medical College Tai'an, China.

出版信息

Int J Clin Exp Med. 2014 Jun 15;7(6):1542-53. eCollection 2014.

Abstract

This meta-analysis was to summarize the published studies about the association between red/processed meat consumption and the risk of lung cancer. 5 databases were systematically reviewed, and random-effect model was used to pool the study results and to assess dose-response relationships. Results shown that six cohort studies and twenty eight case-control studies were included in this meat-analysis. The pooled Risk Radios (RR) for total red meat and processed meat were 1.44 (95% CI, 1.29-1.61) and 1.23 (95% CI, 1.10-1.37), respectively. Dose-response analysis revealed that for every increment of 120 grams red meat per day the risk of lung cancer increases 35% and for every increment of 50 grams red meat per day the risk of lung cancer increases 20%. The present dose-response meta-analysis suggested that both red and processed meat consumption showed a positive effect on lung cancer risk.

摘要

这项荟萃分析旨在总结已发表的关于红肉/加工肉类消费与肺癌风险之间关联的研究。系统检索了5个数据库,并使用随机效应模型汇总研究结果并评估剂量反应关系。结果显示,该肉类分析纳入了6项队列研究和28项病例对照研究。红肉和加工肉类的合并风险比(RR)分别为1.44(95%CI,1.29 - 1.61)和1.23(95%CI,1.10 - 1.37)。剂量反应分析表明,每天红肉摄入量每增加120克,肺癌风险增加35%;每天加工肉类摄入量每增加50克,肺癌风险增加20%。目前的剂量反应荟萃分析表明,红肉和加工肉类消费均与肺癌风险呈正相关。

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