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Acyclovir Dosing in the Neonatal Period and Beyond.
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Management of suspected viral encephalitis in children - Association of British Neurologists and British Paediatric Allergy, Immunology and Infection Group national guidelines.儿童疑似病毒性脑炎的管理 - 英国神经病学家协会和英国儿科过敏、免疫和感染学会国家指南。
J Infect. 2012 May;64(5):449-77. doi: 10.1016/j.jinf.2011.11.013. Epub 2011 Nov 18.
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Oral acyclovir suppression and neurodevelopment after neonatal herpes.新生儿疱疹后口服阿昔洛韦抑制与神经发育。
N Engl J Med. 2011 Oct 6;365(14):1284-92. doi: 10.1056/NEJMoa1003509.
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Diagnostic strategy used to establish etiologies of encephalitis in a prospective cohort of patients in England.在英格兰前瞻性队列研究中,用于确定脑炎病因的诊断策略。
J Clin Microbiol. 2011 Oct;49(10):3576-83. doi: 10.1128/JCM.00862-11. Epub 2011 Aug 24.
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Herpes simplex serious neurological disease in young children: incidence and long-term outcome.儿童单纯疱疹严重神经系统疾病:发病率和长期结局。
Arch Dis Child. 2012 Feb;97(2):162-5. doi: 10.1136/adc.2010.204677. Epub 2011 Jun 17.
6
Herpes simplex virus infection in young infants during 2 decades of empiric acyclovir therapy.20 年经验性阿昔洛韦治疗期间婴幼儿单纯疱疹病毒感染。
Pediatr Infect Dis J. 2011 Jul;30(7):556-61. doi: 10.1097/INF.0b013e31820e3398.
7
Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management.单纯疱疹病毒对核苷类似物的耐药性:机制、流行率和管理。
Antimicrob Agents Chemother. 2011 Feb;55(2):459-72. doi: 10.1128/AAC.00615-10. Epub 2010 Nov 15.
8
Use of therapeutic drug monitoring in the long-term valaciclovir therapy of relapsing herpes simplex virus encephalitis in children.治疗药物监测在儿童复发性单纯疱疹病毒性脑炎长期伐昔洛韦治疗中的应用
J Antimicrob Chemother. 2009 Dec;64(6):1340-1. doi: 10.1093/jac/dkp373. Epub 2009 Oct 14.
9
The management of infants and children treated with aciclovir for suspected viral encephalitis.阿昔洛韦治疗疑似病毒性脑炎的婴儿和儿童的管理。
Arch Dis Child. 2010 Feb;95(2):100-6. doi: 10.1136/adc.2008.144998. Epub 2009 May 19.
10
Herpes simplex virus infection in pregnancy and in neonate: status of art of epidemiology, diagnosis, therapy and prevention.孕期及新生儿单纯疱疹病毒感染:流行病学、诊断、治疗及预防的现状
Virol J. 2009 Apr 6;6:40. doi: 10.1186/1743-422X-6-40.

15分钟会诊:新生儿及儿童疱疹性脑炎的管理

Fifteen minute consultation: managing neonatal and childhood herpes encephalitis.

作者信息

Le Doare K, Menson Esse, Patel Deepak, Lim Ming, Lyall Hermione, Herberg Jethro

机构信息

Wellcome Trust/Imperial Centre for Global Health Research, Imperial College, London, UK.

Department of General Paediatrics, Evelina Children's Hospital, London, UK.

出版信息

Arch Dis Child Educ Pract Ed. 2015 Apr;100(2):58-63. doi: 10.1136/archdischild-2014-306321. Epub 2014 Aug 11.

DOI:10.1136/archdischild-2014-306321
PMID:25112286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4392236/
Abstract

Herpes simplex encephalitis (HSE) is the most common single cause of viral encephalitis in infants and children. Treated or untreated, it can be associated with considerable morbidity and mortality, and its presentation is usually insidious and non-specific. Prompt and careful investigation is important in order to establish the diagnosis so that treatment can be optimised. We address some common questions arising when diagnosing and treating presumed HSE throughout childhood.

摘要

单纯疱疹病毒性脑炎(HSE)是婴幼儿和儿童病毒性脑炎最常见的单一病因。无论是否接受治疗,它都可能导致相当高的发病率和死亡率,其症状通常隐匿且不具特异性。为了确诊以便优化治疗,及时且仔细的检查很重要。我们探讨了在整个儿童期诊断和治疗疑似HSE时出现的一些常见问题。