Minei Joseph P, Fabian Timothy C, Guffey Danielle M, Newgard Craig D, Bulger Eileen M, Brasel Karen J, Sperry Jason L, MacDonald Russell D
*Department of Surgery, University of Texas Southwestern Medical Center, Dallas †Department of Surgery, University of Tennessee Health Science Center, Memphis ‡Department of Biostatistics, University of Washington, Seattle §Department of Emergency Medicine, Oregon Health & Science University, Portland ‖Department of Surgery, University of Washington, Seattle ¶Department of Surgery, Medical College of Wisconsin, Milwaukee **Department of Surgery, University of Pittsburgh, Pittsburgh ††Department of Medicine, University of Toronto, Toronto, Ontario, Canada; and Ornge Transport Medicine, Mississauga, Ontario, Canada; for the Resuscitation Outcome Consortium Investigators.
Ann Surg. 2014 Sep;260(3):456-64; discussion 464-5. doi: 10.1097/SLA.0000000000000873.
To investigate the relationship between trauma center volume and outcome.
The Resuscitation Outcomes Consortium is a network of 11 centers and 60 hospitals conducting emergency care research. For many procedures, high-volume centers demonstrate superior outcomes versus low-volume centers. This remains controversial for trauma center outcomes.
This study was a secondary analysis of prospectively collected data from the Resuscitation Outcomes Consortium multicenter out-of-hospital Hypertonic Saline Trial in patients with Glasgow Coma Scale score of 8 or less (traumatic brain injury) or systolic blood pressure of 90 or less and pulse of 110 or more (shock). Regression analyses evaluated associations between trauma volume and the following outcomes: 24-hour mortality, 28-day mortality, ventilator-free days, Multiple Organ Dysfunction Scale incidence, worst Multiple Organ Dysfunction Scale score, and poor 6-month Glasgow Outcome Scale-Extended score.
A total of 2070 patients were evaluated: 1251 in the traumatic brain injury cohort and 819 in the shock cohort. Overall, 24-hour and 28-day mortality was 16% and 25%, respectively. For every increase of 500 trauma center admissions, there was a 7% decreased odds of 24-hour and 28-day mortality for all patients. As trauma center volume increased, nonorgan dysfunction complications increased, ventilator-free days increased, and worst Multiple Organ Dysfunction Scale score decreased. The associations with higher trauma center volume were similar for the traumatic brain injury cohort, including better neurologic outcomes at 6 months, but not for the shock cohort.
Increased trauma center volume was associated with increased survival, more ventilator-free days, and less severe organ failure. Trauma system planning and implementation should avoid unnecessary duplication of services.
探讨创伤中心规模与治疗结果之间的关系。
复苏结果联盟是一个由11个中心和60家医院组成的网络,开展急诊护理研究。对于许多手术而言,高容量中心的治疗结果优于低容量中心。但创伤中心的治疗结果仍存在争议。
本研究是对复苏结果联盟多中心院外高渗盐水试验前瞻性收集的数据进行的二次分析,研究对象为格拉斯哥昏迷量表评分8分及以下(创伤性脑损伤)或收缩压90及以下且脉搏110及以上(休克)的患者。回归分析评估创伤量与以下结果之间的关联:24小时死亡率、28天死亡率、无呼吸机天数、多器官功能障碍量表发生率、最差多器官功能障碍量表评分以及6个月时不良格拉斯哥预后量表扩展评分。
共评估了2070例患者:创伤性脑损伤队列1251例,休克队列819例。总体而言,24小时和28天死亡率分别为16%和25%。创伤中心入院人数每增加500例,所有患者24小时和28天死亡率的几率降低7%。随着创伤中心规模的增加,非器官功能障碍并发症增加,无呼吸机天数增加,最差多器官功能障碍量表评分降低。创伤性脑损伤队列中,创伤中心规模越大,关联情况相似,包括6个月时神经功能预后更好,但休克队列并非如此。
创伤中心规模的增加与生存率提高、无呼吸机天数增加以及器官衰竭严重程度降低相关。创伤系统的规划和实施应避免不必要的服务重复。