从两种印度尼西亚Stylissa 属海洋海绵中分离得到Dispacamide E 和其他生物活性溴代吡咯生物碱。

Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa.

机构信息

a Institutfür Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine Universität , Geb. 26.23, Universitätsstrasse 1, D-40225 Düsseldorf , Germany.

出版信息

Nat Prod Res. 2015 Feb;29(3):231-8. doi: 10.1080/14786419.2014.947496. Epub 2014 Aug 12.

DOI:10.1080/14786419.2014.947496

PMID:25116895

Abstract

Chemical investigation of methanolic extracts of the two Indonesian marine sponges Stylissa massa and Stylissa flabelliformis yielded 25 bromopyrrole alkaloids including 2 new metabolites. The structures of all isolated compounds were unambiguously elucidated based on extensive 1D and 2D NMR, LR-MS and HR-MS analyses. All isolated compounds were assayed for their antiproliferative and protein kinase inhibitory activities. Several of the tested compounds revealed selective activity(ies) which suggested preliminary SARs of the isolated bromopyrrole alkaloids.

摘要

从印度尼西亚两种海洋海绵Stylissa massa 和 Stylissa flabelliformis 的甲醇提取物中进行化学研究，得到了 25 种溴代吡咯生物碱，包括 2 种新的代谢物。基于广泛的 1D 和 2D NMR、LR-MS 和 HR-MS 分析，明确了所有分离化合物的结构。所有分离出的化合物都进行了抗增殖和蛋白激酶抑制活性的测试。一些测试化合物显示出选择性的活性，这表明分离出的溴代吡咯生物碱的初步 SAR。