Papini Camila Bosquiero, Nakamura Priscila M, Zorzetto Lucas P, Thompson Janice L, Phillips Anna C, Kokubun Eduardo
Department of Physical Education, São Paulo State University, Avenida 24-A, 1515 Bela Vista, 13506-900 Rio Claro, SP, Brazil.
School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
Mediators Inflamm. 2014;2014:185707. doi: 10.1155/2014/185707. Epub 2014 Jul 17.
The aim of this study was to analyze the impact of a community-based exercise program in primary care on inflammatory biomarkers and hormone levels. The 1-year quasiexperimental study involved 13 women (mean age = 56.8 ± 11.4 years) and it was developed in two basic health care units in Rio Claro City, Brazil. The physical exercise intervention was comprised of two, 60-minute sessions/week. The inflammatory biomarkers were measured at baseline, 6 months, and 1 year. Repeated measures ANOVA analyses indicated that the intervention was effective in reducing CRP and TNFα after 1 year compared to baseline and 6 months (P < 0.05). There were no changes in IL10, IL6, and insulin after 1 year. However, leptin significantly increased at 1 year (P = 0.016). The major finding of this study is that a community-based exercise program can result in a decrease or maintenance of inflammatory biomarkers after 1 year, and thus has the potential to be a viable public health approach for chronic disease prevention.
本研究的目的是分析基层医疗中基于社区的运动项目对炎症生物标志物和激素水平的影响。这项为期1年的半实验性研究涉及13名女性（平均年龄 = 56.8 ± 11.4岁），在巴西里奥克拉罗市的两个基本医疗保健单位开展。体育锻炼干预包括每周两次，每次60分钟的课程。在基线、6个月和1年时测量炎症生物标志物。重复测量方差分析表明，与基线和6个月相比，干预在1年后有效降低了CRP和TNFα（P < 0.05）。1年后IL10、IL6和胰岛素没有变化。然而，瘦素在1年时显著增加（P = 0.016）。本研究的主要发现是，基于社区的运动项目在1年后可导致炎症生物标志物降低或维持不变，因此有可能成为预防慢性病的可行公共卫生方法。
