Bowers Michael T
Department of Chemistry & Biochemistry, University of California, Santa Barbara, CA 93106-9510, United States.
Int J Mass Spectrom. 2014 Sep 15;370:75-95. doi: 10.1016/j.ijms.2014.06.016.
Ion mobility is not a newly discovered phenomenon. It has roots going back to Langevin at the beginning of the 20th century. Our group initially got involved by accident around 1990 and this paper is a brief account of what has transpired here at UCSB the past 25 years in response to this happy accident. We started small, literally, with transition metal atomic ions and transitioned to carbon clusters, synthetic polymers, most types of biological molecules and eventually peptide and protein oligomeric assembly. Along the way we designed and built several generations of instruments, a process that is still ongoing. And perhaps most importantly we have incorporated theory with experiment from the beginning; a necessary wedding that allows an atomistic face to be put on the otherwise interesting but not fully informative cross section measurements.
离子迁移并不是一个新发现的现象。它可以追溯到20世纪初的朗之万。我们的团队最初是在1990年左右偶然涉足这个领域的，本文简要介绍了过去25年里在加州大学圣巴巴拉分校（UCSB）因这一幸运的偶然事件所发生的事情。我们从非常小的规模开始，确切地说是从过渡金属原子离子开始，然后转向碳簇、合成聚合物、大多数类型的生物分子，最终是肽和蛋白质寡聚体组装。在此过程中，我们设计并制造了几代仪器，这一过程仍在继续。也许最重要的是，我们从一开始就将理论与实验结合起来；这是一场必要的结合，它能让我们从原子层面理解原本有趣但信息并不完全丰富的截面测量。
