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肾上腺切除术对体内外白细胞介素-1释放的影响。

The effect of adrenalectomy on interleukin-1 release in vitro and in vivo.

作者信息

Perretti M, Becherucci C, Scapigliati G, Parente L

机构信息

Sclavo Research Centre, Siena, Italy.

出版信息

Br J Pharmacol. 1989 Dec;98(4):1137-42. doi: 10.1111/j.1476-5381.1989.tb12657.x.

DOI:10.1111/j.1476-5381.1989.tb12657.x
PMID:2514946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1854829/
Abstract

1 Peritoneal macrophages (M phi) collected from adrenalectomized (ADX) rats released more interleukin-1 (IL-1) activity and prostaglandin E2 (PGE2) than macrophages from sham-operated (SHO) rats. 2 The increase in IL-1 activity in the supernatants was confirmed by the increase of the cell-associated 33 kD IL-1 alpha precursor in ADX macrophages stimulated by lipopolysaccharide (LPS). 3 After the injection of Complete Freund's Adjuvant (CFA) to induce adjuvant arthritis, 60% of the ADX rats died, while no deaths occurred in the SHO group. 4 The in vivo administration of dexamethasone inhibited both IL-1 and PGE2 release by macrophages as well as protecting ADX animals from CFA-induced death. Indomethacin and BW 755C partially protected the animals from this lethal effect. 5 These results suggest that adrenalectomy induces an increased release of IL-1 both in vitro and in vivo, and are consistent with a feedback mechanism between IL-1 and glucocorticoid hormones.

摘要
  1. 从肾上腺切除（ADX）大鼠收集的腹膜巨噬细胞（M phi）比假手术（SHO）大鼠的巨噬细胞释放更多的白细胞介素-1（IL-1）活性和前列腺素E2（PGE2）。2. 脂多糖（LPS）刺激ADX巨噬细胞后，细胞相关的33 kD IL-1α前体增加，证实了上清液中IL-1活性的增加。3. 注射完全弗氏佐剂（CFA）诱导佐剂性关节炎后，60%的ADX大鼠死亡，而SHO组未发生死亡。4. 地塞米松的体内给药抑制巨噬细胞释放IL-1和PGE2，并保护ADX动物免于CFA诱导的死亡。吲哚美辛和BW 755C部分保护动物免受这种致死作用。5. 这些结果表明，肾上腺切除在体外和体内均诱导IL-1释放增加，并且与IL-1和糖皮质激素之间的反馈机制一致。
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f9/1854829/9f9f99e8101c/brjpharm00264-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f9/1854829/9f9f99e8101c/brjpharm00264-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f9/1854829/9f9f99e8101c/brjpharm00264-0067-a.jpg

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