• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
High expression of transcription factor 4 (TCF4) is an independent adverse prognostic factor in acute myeloid leukemia that could guide treatment decisions.转录因子4（TCF4）的高表达是急性髓系白血病中一个独立的不良预后因素，可指导治疗决策。
Haematologica. 2014 Dec;99(12):e257-9. doi: 10.3324/haematol.2014.110437. Epub 2014 Aug 22.
2
Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma.使用 ChIP-seq 绘制 TCF4 和 STAT3 靶点的全基因组独特图谱，揭示它们与胶质母细胞瘤新的分子亚型的关联。
Neuro Oncol. 2013 Mar;15(3):279-89. doi: 10.1093/neuonc/nos306. Epub 2013 Jan 7.
3
Nuclear LEF1/TCF4 correlate with poor prognosis but not with nuclear β-catenin in cerebral metastasis of lung adenocarcinomas.核 LEF1/TCF4 与不良预后相关，但与肺腺癌脑转移中的核 β-连环蛋白无关。
Clin Exp Metastasis. 2013 Apr;30(4):471-82. doi: 10.1007/s10585-012-9552-7. Epub 2012 Dec 8.
4
Expression profiling of cancer-related galectins in acute myeloid leukemia.急性髓系白血病中癌症相关半乳糖凝集素的表达谱分析。
Tumour Biol. 2015 Sep;36(10):7929-39. doi: 10.1007/s13277-015-3513-0. Epub 2015 May 9.
5
Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia.Wnt抑制剂CXXC5的下调预示急性髓系白血病预后较好。
Blood. 2015 May 7;125(19):2985-94. doi: 10.1182/blood-2014-12-613703. Epub 2015 Mar 24.
6
MN1, FOXP1 and hsa-miR-181a-5p as prognostic markers in acute myeloid leukemia patients treated with intensive induction chemotherapy and autologous stem cell transplantation.MN1、FOXP1和hsa-miR-181a-5p作为接受强化诱导化疗和自体干细胞移植的急性髓系白血病患者的预后标志物。
Leuk Res. 2020 Feb;89:106296. doi: 10.1016/j.leukres.2020.106296. Epub 2020 Jan 3.
7
The outcomes of relapsed acute myeloid leukemia in children: Results from the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05R study.儿童复发急性髓系白血病的结局：来自日本儿科白血病/淋巴瘤研究组 AML-05R 研究的结果。
Pediatr Blood Cancer. 2021 Jan;68(1):e28736. doi: 10.1002/pbc.28736. Epub 2020 Sep 29.
8
Up-regulation of DDIT4 predicts poor prognosis in acute myeloid leukaemia.上调 DDIT4 预测急性髓系白血病预后不良。
J Cell Mol Med. 2020 Jan;24(1):1067-1075. doi: 10.1111/jcmm.14831. Epub 2019 Nov 21.
9
WT1 Expression in Adult Acute Myeloid Leukemia: Assessing its Presence, Magnitude and Temporal Changes as Prognostic Factors.WT1在成人急性髓系白血病中的表达：评估其作为预后因素的存在情况、程度及时间变化
Pathol Oncol Res. 2016 Jan;22(1):217-21. doi: 10.1007/s12253-015-0002-0. Epub 2015 Nov 4.
10
Outcomes of Intermediate Risk Karyotype Acute Myeloid Leukemia in First Remission Undergoing Autologous Stem Cell Transplantation Compared With Allogeneic Stem Cell Transplantation and Chemotherapy Consolidation: A Retrospective, Propensity-score Adjusted Analysis.自体干细胞移植与异基因干细胞移植及化疗巩固治疗相比，首次缓解的中危核型急性髓系白血病的疗效：一项回顾性、倾向评分调整分析
Clin Lymphoma Myeloma Leuk. 2018 Nov;18(11):e481-e491. doi: 10.1016/j.clml.2018.07.290. Epub 2018 Jul 17.

引用本文的文献

1
A Novel Prognostic Risk-Scoring Model Based on RAS Gene-Associated Cluster in Pediatric Acute Myeloid Leukemia.基于RAS基因相关簇的儿童急性髓系白血病新型预后风险评分模型
Cancer Med. 2025 Mar;14(5):e70716. doi: 10.1002/cam4.70716.
2
IRE1α-XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs.IRE1α-XBP1通过限制促白血病基因程序来保护造血干细胞和祖细胞。
Nat Immunol. 2025 Feb;26(2):200-214. doi: 10.1038/s41590-024-02063-w. Epub 2025 Jan 9.
3
Acute myeloid leukemia associated RUNX1 variants induce aberrant expression of transcription factor TCF4.急性髓系白血病相关的RUNX1变体诱导转录因子TCF4的异常表达。
Leukemia. 2025 Feb;39(2):520-523. doi: 10.1038/s41375-024-02470-w. Epub 2024 Dec 12.
4
HMX3 is a critical vulnerability in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemia.HMX3是MECOM阴性KMT2A::MLLT3急性粒单核细胞白血病中的一个关键漏洞。
Leukemia. 2025 Feb;39(2):371-380. doi: 10.1038/s41375-024-02485-3. Epub 2024 Dec 4.
5
Transcription factor 4 is a key mediator of oncogenesis in neuroblastoma by promoting MYC activity.转录因子4通过促进MYC活性，是神经母细胞瘤肿瘤发生的关键介质。
Mol Oncol. 2025 Mar;19(3):808-824. doi: 10.1002/1878-0261.13714. Epub 2024 Aug 9.
6
Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer.冬凌草甲素通过 TP53 抑制的 TCF4 反式激活促进结直肠癌细胞内质网应激。
J Exp Clin Cancer Res. 2023 Jun 19;42(1):150. doi: 10.1186/s13046-023-02702-4.
7
LncRNA ANRIL/miR-7-5p/TCF4 axis contributes to the progression of T cell acute lymphoblastic leukemia.长链非编码RNA ANRIL/微小RNA-7-5p/转录因子4轴促进T细胞急性淋巴细胞白血病的进展。
Cancer Cell Int. 2020 Jul 23;20:335. doi: 10.1186/s12935-020-01376-8. eCollection 2020.
8
HMGA Proteins in Hematological Malignancies.血液系统恶性肿瘤中的HMGA蛋白
Cancers (Basel). 2020 Jun 3;12(6):1456. doi: 10.3390/cancers12061456.
9
Tyrosine Kinase Inhibitor Imatinib Mesylate Alters DMBA-Induced Early Onco/Suppressor Gene Expression with Tissue-Specificity in Mice.甲磺酸伊马替尼（酪氨酸激酶抑制剂）改变 DMBA 诱导的小鼠组织特异性早期癌/抑癌基因表达。
Biomed Res Int. 2019 Feb 7;2019:8670398. doi: 10.1155/2019/8670398. eCollection 2019.
10
RUNX1 mutations enhance self-renewal and block granulocytic differentiation in human in vitro models and primary AMLs.RUNX1 突变增强了人类体外模型和原发性 AML 中的自我更新并阻断了粒细胞分化。
Blood Adv. 2019 Feb 12;3(3):320-332. doi: 10.1182/bloodadvances.2018024422.

本文引用的文献

1
Clinical and biological implications of driver mutations in myelodysplastic syndromes.骨髓增生异常综合征中驱动突变的临床和生物学意义。
Blood. 2013 Nov 21;122(22):3616-27; quiz 3699. doi: 10.1182/blood-2013-08-518886. Epub 2013 Sep 12.
2
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.成人新发急性髓系白血病的基因组和表观基因组图谱。
N Engl J Med. 2013 May 30;368(22):2059-74. doi: 10.1056/NEJMoa1301689. Epub 2013 May 1.
3
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.Musashi-2 调节正常造血并促进侵袭性髓性白血病。
Nat Med. 2010 Aug;16(8):903-8. doi: 10.1038/nm.2187. Epub 2010 Jul 8.
4
Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet.成人急性髓系白血病的诊断和治疗：代表欧洲白血病网的国际专家小组的建议。
Blood. 2010 Jan 21;115(3):453-74. doi: 10.1182/blood-2009-07-235358. Epub 2009 Oct 30.
5
Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome.双CEBPA突变而非单CEBPA突变定义了急性髓系白血病的一个亚组，该亚组具有独特的基因表达谱，且与良好预后唯一相关。
Blood. 2009 Mar 26;113(13):3088-91. doi: 10.1182/blood-2008-09-179895. Epub 2009 Jan 26.
6
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.由MLL-AF9引发的从定向祖细胞向白血病干细胞的转变。
Nature. 2006 Aug 17;442(7104):818-22. doi: 10.1038/nature04980. Epub 2006 Jul 16.
7
ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.ITF-2是Wnt/TCF信号通路的下游靶点，在伴有β-连环蛋白缺陷的人类癌症中被激活，并促进肿瘤转化。
Cancer Cell. 2002 Mar;1(2):145-55. doi: 10.1016/s1535-6108(02)00035-1.
8
Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth.A类螺旋-环-螺旋蛋白是几种细胞周期蛋白依赖性激酶抑制剂启动子活性的正调节因子，并对细胞生长产生负面影响。
Cancer Res. 2000 Mar 1;60(5):1376-82.
9
Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms.螺旋-环-螺旋蛋白：真核生物中的转录调节因子。
Mol Cell Biol. 2000 Jan;20(2):429-40. doi: 10.1128/MCB.20.2.429-440.2000.
10
A splice variant of E2-2 basic helix-loop-helix protein represses the brain-specific fibroblast growth factor 1 promoter through the binding to an imperfect E-box.E2-2碱性螺旋-环-螺旋蛋白的一种剪接变体通过与一个不完全E盒结合来抑制脑特异性成纤维细胞生长因子1启动子。
J Biol Chem. 1998 Jul 24;273(30):19269-76. doi: 10.1074/jbc.273.30.19269.

High expression of transcription factor 4 (TCF4) is an independent adverse prognostic factor in acute myeloid leukemia that could guide treatment decisions.

作者信息

in 't Hout Florentien E M, van der Reijden Bert A, Monteferrario Davide, Jansen Joop H, Huls Gerwin

机构信息

Department of Laboratory medicine, Laboratory of Hematology, RadboudUMC; and Department of Hematology, RadboudUMC, Nijmegen, The Netherlands.

Department of Laboratory medicine, Laboratory of Hematology, RadboudUMC; and.

出版信息

Haematologica. 2014 Dec;99(12):e257-9. doi: 10.3324/haematol.2014.110437. Epub 2014 Aug 22.

DOI:10.3324/haematol.2014.110437
PMID:25150259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4258745/
Abstract
摘要