Medvedev D I, Babichenko I I, Kravtsova A I, Eremina I Z
Arkh Anat Gistol Embriol. 1989 Oct;97(10):20-5.
An electron microscopical investigation of the cerebellar cortex has been carried out in mice, kept during the 10th-40th days of their life at a diet with protein insufficiency and a subsequent food rehabilitation and food rehabilitation with carnitine addition to the diet on the 41st-70th days of their life. A sharp protein limitation in the diet results in the most essential changes in the neuropil, while the ultrastructure of the piriform neurons changes slightly. Amount of the synaptic vesicles in small axonal terminals decreases and their localization in the area of the synaptic contacts changes. Simultaneously, degeneratively changed axonal terminals often occur, they demonstrate a rather electron opaque axoplasma. The food rehabilitation mainly normalizes the ultrastructure of the cerebellar cortex elements, however, in the neuropil altered axonal terminals with a high electron opaque axoplasma occur. After the food rehabilitation with carnitine addition to the diet, the cerebellar cortex ultrastructure not only normalizes, but even demonstrates certain signs of hypertrophy.
对小鼠小脑皮质进行了电子显微镜研究。这些小鼠在出生后第10至40天食用蛋白质不足的饮食，随后进行食物恢复，并在出生后第41至70天在饮食中添加肉碱进行食物恢复。饮食中蛋白质的严重限制导致神经纤维网发生最本质的变化，而梨状神经元的超微结构变化较小。小轴突终末中突触小泡的数量减少，其在突触接触区域的定位发生变化。同时，经常出现退行性改变的轴突终末，它们表现出相当电子致密的轴浆。食物恢复主要使小脑皮质元件的超微结构正常化，然而，在神经纤维网中会出现具有高电子致密轴浆的改变的轴突终末。在饮食中添加肉碱进行食物恢复后，小脑皮质的超微结构不仅正常化，甚至还表现出一定的肥大迹象。
