Medvedev D I, Babichenko I I, Eremina I Z, Kravtsova A I
Biull Eksp Biol Med. 1985 Dec;100(12):751-4.
Electron microscopy of mouse neocortex was carried out during rehabilitation following long-term protein-caloric deficiency. Food rehabilitation led to partial recovery of brain ultrastructure, however, a high neuronal level of secondary lysosoms and lipofuscin bodies was preserved, with the changes in the spine apparatus and synaptic contacts persisting in neuropile. Carnitine addition to food during rehabilitation increased the number of free ribosomes in cortical neurons. A substantial development of granular endoplasmic reticulum was observed. A greater number of spine apparatus cisterns was detected, however, like in conventional rehabilitation, the width of synaptic clefts and postsynaptic densities remained narrower than in control mice.
在长期蛋白质热量缺乏后的康复过程中，对小鼠新皮层进行了电子显微镜检查。食物康复导致脑超微结构部分恢复，然而，神经元中次级溶酶体和脂褐素体的高水平得以保留，神经毡中棘器和突触接触的变化持续存在。康复期间在食物中添加肉碱增加了皮质神经元中游离核糖体的数量。观察到粗面内质网有显著发育。检测到更多的棘器池，然而，与传统康复一样，突触间隙和突触后密度的宽度仍比对照小鼠窄。
