[长期蛋白质-热量营养不良后康复期间小鼠新皮质突触连接的超微结构变化]

[Ultrastructural changes in synaptic junctions of the mouse neocortex during rehabilitation after prolonged protein-calorie malnutrition].

作者信息

Medvedev D I, Babichenko I I, Eremina I Z, Kravtsova A I

出版信息

Biull Eksp Biol Med. 1988 Jun;105(6):726-8.

Abstract

The quantitative ultrastructural study of neocortical synaptic junctions has been performed during rehabilitation after protein-caloric deficiency. It has been shown that simple food rehabilitation does not lead to absolute restoration of synaptic junctions. However, food rehabilitation with carnitine restores the ultrastructure of synaptic junctions, with the length of the active zones and the number of spine apparatus cisterns exceeding the control values. Nevertheless, synaptic cleft width and postsynaptic density remain lower than in the control group, both after simple food rehabilitation and food rehabilitation with carnitine.

摘要

在蛋白质 - 热量缺乏后的康复过程中，对新皮质突触连接进行了定量超微结构研究。结果表明，单纯的食物康复并不能导致突触连接的完全恢复。然而，添加肉碱的食物康复可恢复突触连接的超微结构，其活性区长度和棘器池数量超过对照组值。尽管如此，无论是单纯食物康复还是添加肉碱的食物康复后，突触间隙宽度和突触后密度仍低于对照组。

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