Medvedev D I, Bonartsev P D, Babichenko I I, Kravtsova A I, Eremina I Z
Biull Eksp Biol Med. 1983 Mar;95(3):114-6.
The changes in the distribution of dark, light and intermediate pyriform neurocytes (Purkinje's cells) in the cerebellum of mice which developed under the conditions of protein-caloric deficiency were assayed from the 10th to the 40th day of mouse life. In the control animals, the number of dark cells was 7 +/- 3%, of intermediate 44 +/- 7%, and that of light ones 49 +/- 7%. Under malnutrition the number of dark cells rose to 26 +/- 5% (P less than 0.01), that of intermediate cells fell to 33 +/- 6% (P less than 0.01), and the number of light cells changed insignificantly (41 +/- 6%, P less than 0.1). Electron microscopy of the ultrastructure of dark cells has disclosed dystrophic and destructive changes in the nucleus and in the main organelles of the cytoplasm. Pronounced astroglial reaction was not infrequently observed around dark cells.
在小鼠出生后第10天至第40天期间，对在蛋白质 - 热量缺乏条件下发育的小鼠小脑内深色、浅色和中间型梨状神经细胞（浦肯野细胞）的分布变化进行了测定。在对照动物中，深色细胞的数量为7±3%，中间型细胞为44±7%，浅色细胞为49±7%。在营养不良的情况下，深色细胞的数量上升至26±5%（P＜0.01），中间型细胞的数量降至33±6%（P＜0.01），而浅色细胞的数量变化不显著（41±6%，P＜0.1）。对深色细胞超微结构的电子显微镜检查揭示了细胞核和细胞质主要细胞器中的营养不良性和破坏性变化。在深色细胞周围经常观察到明显的星形胶质细胞反应。
